Scholpp_Lab

@[email protected]
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13 Posts
We are interested in cell-cell communication, morphogens, Wnt signalling, zebrafish, cancer, neurodegenerative diseases and cytonemes.
https://biosciences.exeter.ac.uk/staff/profile/index.php?web_id=Steffen_Scholppscience
zebrafishWnt signalling
gastric cancerdevelopmental biology
cell biologyacademia
Scholpp_LabAug 15, 2024
Now, I have some questions: I wondered how to find and connect to all the fantastic and inspirational scientists if they are based on other servers. I found some, like @CellySally, @jamesbriscoe, and @amjeve. Did I start my account on the wrong server? Where are the other cell and dev biologists from the UK? I would like to read about cool new publications/preprints. Thanks.
Scholpp_LabAug 15, 2024
It took me some time, but the latest events on Twitter made it obvious to me that this is not a platform that I want to support. Therefore I moved to mstdn.
Scholpp_LabAug 15, 2024
Excited to be on my way to #IZFC2024 #zebrafish #izfs2024 #izfs. Looking forward to lots of cool discussions about signalling, Wnt, and zebrafish! And meeting lots of zebbie friends and colleagues. Kyoto, here we come!
Scholpp_LabAug 13, 2024
Here are the articles: https://pubmed.ncbi.nlm.nih.gov/37722040/ and here: https://pubmed.ncbi.nlm.nih.gov/38123680/ Let me hear what you think?
Cancer-associated fibroblasts influence Wnt/PCP signaling in gastric cancer cells by cytoneme-based dissemination of ROR2 - PubMed

Cancer-associated fibroblasts (CAFs) are a crucial component in the tumor microenvironment influencing cancer progression. Besides shaping the extracellular matrix, these fibroblasts provide signaling factors to facilitate tumor survival and alter tumor behavior. In gastric cancer, one crucial signa …

PubMed
Scholpp_LabAug 13, 2024
Have we just challenged the long-standing concept of Waddington and Spemann? Or do we need an extended model?
Scholpp_LabAug 13, 2024
What happens if a cell receives receptors via cytonemes - can it acquire a new competence? Adopt a competence? Can this adoptive competence override the innate competence?
Show threadScholpp_LabAug 13, 2024
Therefore, competence is foremost defined by the availability of the appropriate receptor to be able to respond to a particular signal (ability to react).
Scholpp_LabAug 13, 2024
What is cellular competence? According to Spemann and Waddington, competence is the ability to respond to an inducing signal. Waddington visualized this concept through his famous epigenetic landscape model, where development is guided along stable paths (canals) despite potential perturbations.
Scholpp_LabAug 13, 2024
Our work reveals that in zebrafish embryos, Wnt5b and Ror2 are transported via cytonemes to initiate Wnt-PCP signalling, challenging traditional views on cellular responsiveness and competence based solely on receptor expression https://nature.com/articles/s41586-023-06850-7 @UK_Wnt
@LSI_Exeter
Scholpp_LabAug 13, 2024
We moved from [email protected] to [email protected]