James Briscoe

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Developmental Biologist working @TheCrick Neural tube, morphogens and transcriptional networks. Editor-in-chief @Dev_journal

London · briscoelab.org

Enjoying #kitpqbio Coming to the end of the first week at beautiful
@KITP_UCSB

Lots of inspiring talks & provocative discussion - many now online
https://online.kitp.ucsb.edu/online/morpho23/

See my (personal perspective) intro into morphogen controlled tissue patterning
https://online.kitp.ucsb.edu/online/morpho23/briscoe/

KITP Program: Dynamics of Self-Organization in Animal and Plant Development

The fabric of developmental time

Insightful commentary in @Dev_journal on how time is measured and regulated in development & the question of how developmental timing differs between species

https://journals.biologists.com/dev/article/150/14/dev201045/323885/On-time-developmental-timing-within-and-across

On time: developmental timing within and across species

Summary: The timing of developmental events is crucial for normal embryogenesis. In this Spotlight, we discuss how time is measured and regulated in development, and question whether it is truly different between species.

The Company of Biologists

"Is there a recent review of the #morphogen control of tissue patterning that I can read on my summer hols?" I hear you ask

Why, yes, there is. Here's @AKicheva & my summary of the current state of the field & open questions

https://www.annualreviews.org/doi/10.1146/annurev-cellbio-020823-011522?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed

@jamesbriscoe Congratulations Rory Daniel & @jamesbriscoe
Your #PaperThemeTune is "A Design For Life" by The Dynamical Street Preachers

Our latest: Deep dynamical modelling of developmental trajectories with temporal transcriptomics

- Optimised metabolic labelling for time resolved scRNAseq
- Deep learning (VAE) for RNA velocity
- Predicting expression dynamics with a neural SDE system

https://www.biorxiv.org/content/10.1101/2023.07.06.547989v1

Confirming UK membership of Horizon Europe would be very good news & end all the unnecessary uncertainty

I'm hoping Sunak doesn't lose his signing pen over the weekend

BBC News - Horizon research deal with EU awaits Sunak's signature
https://www.bbc.co.uk/news/science-environment-66116938

Horizon research deal with EU awaits Sunak's signature

BBC News understands a deal has been negotiated over UK association with the Horizon programme.

BBC News

Congratulations to new #EMBO members including my fellow developmental biologists Anne Grapin Botton & Kathy Cheah (+ several others)

https://www.embo.org/press-releases/embo-announces-election-of-new-members/

EMBO announces election of new members – Press releases – EMBO

69 new members and associate members join the EMBO community of more than 2,000 leading life scientists in Europe and beyond

EMBO

ICYMI: Recordings of a fantastic symposium organised by the inimitable Denis Duboule on 'Developmental Timing'

Jean Leon Maitre
Thomas Gregor
Claude Desplan
Pierre Vanderhaeghen
Olivier Pourquie
& yours truly

https://www.college-de-france.fr/fr/agenda/colloque/les-temps-du-developpement-embryonnaire

Les temps du développement embryonnaire / The Times of Embryonic Development | Collège de France