IAP proteins play central roles in regulating apoptosis - Lopes et al. show that IAP expansion in animals has repeatedly emerged through lineage-specific duplication events

🔗 https://doi.org/10.1093/molbev/msag078

#evobio #molbio

Goff et al. measure collateral fitness landscapes of TEM-1 β-lactamase in conditions expected to alter protein aggregation or stability, proposing that mutational destabilization is associated with deleterious collateral fitness effects.

🔗 https://doi.org/10.1093/molbev/msag106

#evobio #molbio

Li et al. present a genomic reassessment of the endangered black-and-white snub-nosed monkey, suggesting the species is divided into five genetically distinct clusters.

🔗 doi.org/10.1093/molbev/msag104

📷 Xinming He

#evobio #molbio

The May issue of MBE is here, featuring the work of Topaloudis et al., who evaluated genotype imputation accuracy in a large barn owl low-coverage WGS dataset.

🔗 https://academic.oup.com/mbe/issue/43/5

📷 Alex Labhardt

#evobio #molbio

Berruga-Fernández et al. show that bacterial hybrid chromosome formation driven by conjugative mobile genetic elements may be an important and widespread mechanism in the emergence and evolution of high-risk bacterial pathogens.

🔗 https://doi.org/10.1093/molbev/msag085

#evobio #molbio #bacteria

Ceriotti et al. investigate the rewiring of organellar translation in the holoparasitic Balanophoraceae, revealing extreme changes in the anciently conserved machinery of plant organellar translation.

🔗 https://doi.org/10.1093/molbev/msag077

📷 Tuber and two inflorescences of the holoparasitic plant Lophophytum pyramidale collected from Parque Nacional Calilegua, Argentina

#evobio #molbio

Pinto et al. present SCINKD as a framework to identify unannotated sex chromosomes and curate diploid genome assemblies from a single individual.

🔗 https://doi.org/10.1093/molbev/msag067

#evobio #molbio #compbio

Cui et al. investigate the evolutionary trajectory leading to dim-light vision in vertebrates, concluding that it evolved via three main stages of molecular adaptation, at the origins of ancestral rhodopsin pigments.

🔗 https://doi.org/10.1093/molbev/msag096

#evobio #molbio #opsin

Cochetel & Cantu publish a new MBE Review on plant pangenomes, outlining major paradigms from gene-based catalogs to haplotype-resolved graphs, core and variable compartments, and how graph-based frameworks enable analyses that are difficult with single linear references.

🔗 https://doi.org/10.1093/molbev/msag087

#evobio #molbio #pangenome

[molbio] PCR is a (Surprisingly) Near-Optimal Technology
https://nikomc.com/2026/04/22/pcr/
https://news.ycombinator.com/item?id=47866215

#MolecularBiology #molbio #PCR #MolecularGenetics #BiologicalEngineering