MicroRNAs unveiled: Nobel recognition of a revolutionary gene regulation mechanism
https://doi.org/10.1016/j.hlife.2024.11.002
#MicroRNAs #miRNAs #academics #AcademicChatter #AcademicTwitter
#MicroRNAs play a crucial role in #plant communication within the #rhizosphere, shaping #growth, #development, and resilience to biotic and abiotic stresses. Learn more in a new #JIPB paper by Fahad et al.!
https://doi.org/10.1111/jipb.13860
@wileyplantsci
#PlantSci #roots #botany #OpenAccess 🔓

Researchers hit the target: they transport #microRNAs against #MuscularDystrophy to muscle stem cells using nanoparticles.

🎯 Treated mice showed improved muscle strength.

+info: https://nanociencia.imdea.org/home-en/news/item/researchers-hit-the-target-they-transport-micrornas-against-muscular-dystrophy-to-muscle-stem-cells-using-nanoparticles #IMDEAnanoPublications

Researchers hit the target: they transport microRNAs against Muscular Dystrophy to muscle stem cells using nanoparticles

Unraveling the #molecular basis of non-host resistance is crucial to improve #crop resilience.
In a new study, Mei et al. report that #rice-specific #microRNAs attack #Sclerotinia via cross-kingdom RNAi. https://doi.org/10.1111/jipb.13840
@wileyplantsci
#PlantSci #CropSci #rapeseed #botany
Exploring cadmium-induced alterations in the expression profile of microRNAs

Cadmium (Cd), a toxic heavy metal, has been identified as a significant environmental pollutant due to its widespread industrial use and persistence in the environment. Chronic exposure to Cd poses a considerable threat to human health, as it accumulates in various tissues over time, leading to numerous diseases.

Phys.org
Deregulation of miR‐1245b‐5p and miR‐92a‐3p and their potential target gene, GATA3, in epithelial–mesenchymal transition pathway in breast cancer. https://doi.org/10.1002/cnr2.1955 #BreastCancer #Epithelial‐MesenchymalTransition #Gata3 #Micrornas
#microRNAs slow translating #ribosomes to prevent protein #misfolding in eukaryotes
Hiroaki Sako, Tadashi Yamamoto and colleagues
The unusual presence of #miRNAs targeting protein-coding sequences is shown to influence ribosome speed, thereby allowing time for accurate #polypeptide folding during protein translation.
https://www.embopress.org/doi/full/10.15252/embj.2022112469

Small but mighty!

miRNA cluster miR-17-92 knock out results in complete testis to ovary #SexReversal.

#preLightsAmbassador Martin Estermann highlights work from Alicia Hurtado and team in which a novel role for #microRNAs is uncovered. #preprint

https://prelights.biologists.com/highlights/complete-male-to-female-sex-reversal-in-xy-mice-lacking-the-mir-17%e2%88%bc92-cluster/

A fast and efficient method for detecting microRNAs

In the early 1990s, scientists who were studying the development of a roundworm identified a small RNA molecule that regulated the expression of specific genes. This marked the discovery of microRNAs (miRNAs), which are now known to be present across all forms of life. As it turns out, these molecules play essential roles in many biological processes.

Phys.org
In a new large-scale #genetic analysis, #scientists have found a set of small #RNA molecules, called #microRNAs, in human #pancreatic cells that are strongly associated with type 2 #diabetes.
#Biology #Medical #sflorg
https://www.sflorg.com/2023/02/bio02092306.html
Large-scale genetic analysis shows microRNAs in human pancreas associated with diabetes

NIH study identifies new molecules involved in diabetes.