Patrick van der WelSep 18, 2023
Interesting webinar about #HuntingtonsDisease is coming on Sept 28th 2023, via the #HDF foundation: https://www.hdfoundation.org/webinars
An online presentation by Judith Frydman and Natalia Barbosa (#Stanford) talking about “How expanding our knowledge of the Huntington's protein can unlock new therapies”. (A statement I fully agree with - to address a protein misfolding disease like HD, we need to understand what this #misfolding process really is!) #polyQ #huntingtondisease #biophysics
HDF Webinars — Hereditary Disease Foundation

Hereditary Disease Foundation
The EMBO JournalAug 4, 2023
#microRNAs slow translating #ribosomes to prevent protein #misfolding in eukaryotes
Hiroaki Sako, Tadashi Yamamoto and colleagues
The unusual presence of #miRNAs targeting protein-coding sequences is shown to influence ribosome speed, thereby allowing time for accurate #polypeptide folding during protein translation.
https://www.embopress.org/doi/full/10.15252/embj.2022112469
CellBioNewsJul 28, 2023

Researchers discover how #mitochondria call for help when under #stress.

#signalling #proteins #misfolding #chaperonins #transcriptomics #DNAJA1 #HSP70

https://phys.org/news/2023-07-mitochondria-stress.html

Researchers discover how mitochondria call for help when under stress

As life propagated across Earth in the form of the widest variety of single-celled organisms, sometime between 3.5 and 1 billion years ago one such organism managed an evolutionary coup: Instead of devouring and digesting bacteria, it encapsulated its prey and used it as a source of energy. As a host cell, it offered protection and nutrition in return.

Phys.org