RE: https://mastodon.social/@HafizHusnain/115328490796649616
This review connects molecular biology and clinical neuroscience, showing how #miRNAs could transform how we diagnose and treat neurodegenerative diseases.
Click Here to Access Full Article: https://rdcu.be/eJJJ3
#Neuroscience #Neurodegeneration #Biomarkers #miRNA #MolecularBiology #Alzheimers #Parkinsons #ALS #Huntingtons #biosensors #NGS #Diagnostics #Therapeutics #AcademicMastodon #OpenScience #springernature
We've got your ticket for summer blockbuster season!
First up: "Fast and furious: The rapid turnover of microRNAs in plants." Explore the #evolutionary & #biological significance of #plant #miRNAs with Guo et al.
https://doi.org/10.1111/jse.13158
@WileyEcolEvol
#PlantSci #evolution #JSE #botany 🔓
Environmentally induced variation in sperm sRNAs is linked to gene expression and transposable elements in zebrafish offspring.
#Transposons #sRNAs #miRNAs #piRNAs #Sperm #Competition #Zebrafish
Environmental factors affect not only paternal condition but may translate into the following generations where sperm-mediated small RNAs (sRNAs) can contribute to the transmission of paternal effects. sRNAs play a key role in the male germ line in genome maintenance and repair, and particularly in response to environmental stress and the resulting increase in transposable element (TE) activity. Here, we investigated how the social environment (high competition, low competition) of male zebrafish Danio rerio affects sRNAs in sperm and how these are linked to gene expression and TE activity in their offspring. In a first experiment, we collected sperm samples after exposing males to each social environment for 2 weeks to test for differentially expressed sperm micro- (miRNA) and piwi-interacting RNAs (piRNA). In a separate experiment, we performed in vitro fertilisations after one 2-week period using a split-clutch design to control for maternal effects and collected embryos at 24 h to test for differentially expressed genes and TEs. We developed new computational prediction tools to link sperm sRNAs with differentially expressed TEs and genes in the embryos. Our results support the idea that the molecular stress response in the male germ line has significant down-stream effects on the molecular pathways, and we provide a direct link between sRNAs, TEs and gene expression.
DGCR8 haploinsufficiency leads to primate-specific RNA dysregulation and pluripotency defects.
#22q112DeletionSyndrome #22qDS #DGCR8 #PluripotentCells #HumanEmbryonicStemCells #miRNAs #EndogenousRetroviruses #HERVH
This study aims to screen and identify specific cluster miRNAs of H7N9 virus-infected N2a cells and explore the possible pathogenesis of these miRNAs. The N2a cells are infected with H7N9 and H1N1 influenza viruses, and the cells are collected at 12, 24 and 48 h to extract total RNA. To sequence miR …
Cyclic #RNA switches that regulate #gene #expression in a cell type-specific manner.
https://phys.org/news/2023-02-cyclic-rna-gene-cell-type-specific.html
The Hirohide Saito Laboratory has developed cyclic RNA switches that can control gene expression in a cell type-specific manner using miRNAs and RNA-binding proteins and has successfully constructed an artificial gene circuit by combining them.
"This review aims to consolidate past and current studies investigating the complexity of the miRNA interactome to provide the reader with a mechanistic view of how miRNAs shape macrophage behavior."
hLife_Journal
Husnain
J of Systematics and Evolution
Amelia Cervera 🧬
The EMBO Journal
Giuseppe Michieli
CellBioNews
Thiago Carvalho