Leukocyte Adhesion Deficiency (LAD Type 1): Delayed Umbilical Cord Separation & Recurrent Infections | USMLE Immunology

Learn how to identify Leukocyte Adhesion Deficiency Type 1 (LAD-1) on USMLE-style questions. Understand the hallmark features — delayed cord separation, recurrent bacterial infections without pus, and CD18 deficiency — with diagnostic reasoning and high-yield immunology insights.

mymedschool.org
Severe Combined Immunodeficiency (SCID) — IL-2 Receptor Gamma Chain Mutation Explained | USMLE Immunology

Understand the clinical clues and genetic basis of Severe Combined Immunodeficiency (SCID). Learn how IL-2 receptor gamma chain mutations lead to T-cell and B-cell dysfunction — a high-yield concept for USMLE Step 1 and Step 2 exams.

mymedschool.org
Participe no nosso Encontro de Famílias com IDP 2025 com grande foco no novo projeto Crescer com IDP para crianças e jovens. #WPIW2025 #SeeTheUnseen #WPIW #WorldPiWeek #Immunodeficiency

It's my birthday and I'm sick and it's alright.

I had #longcovid in 2022 and developed an #immunodeficiency (igg2 SAD) from it. I basically spent a good part of that year in bed. It was a pause on my whole life, and I'm still rebuilding it.

I learned some skills for this moment that I forget when I'm well. Mostly: you can't do anything when you're not caring for yourself. And in periods of overwhelm, next right action is the only thing that matters - to yourself and the collective

spoke too soon. Feeling worse and better in waves. Uncontrollable shivering earlier, now laying in bed with oxygen, feeling at least... decent. #immunodeficiency sucks. #SitTogether
According to an excellent explanation from #TACT the wave of mystery pneumonias follows in time and space any wave of #pirola aka the #BA286 family.
In particular the most infectious variant to date, #JN1 "with extreme immune evasion and suppression". In other words, this is the variant most likely to induce #immunodeficiency.
Anything that can cause "secondary" pneumonia is on the list, particularly in children and the elderly whose immune systems are already weakened.
⚠️ At the end of the article, there is a warning that adults will be the next to be affected, in the coming weeks.
Source: https://tactnowinfo.substack.com/p/the-cause-of-the-mysterious-pneumonia?utm_source=post-email-title&publication_id=1225454&post_id=139291689&utm_campaign=email-post-title&isFreemail=true&r=lr6zj&utm_medium=email
#COVID #Immunodefficiency #Pneumonia #MysteriousDisease
The Cause of the Mysterious Pneumonia Surging in China, South Korea, France, Netherlands, Denmark and the U.S. is Revealed

We uncover what's behind the surge in respiratory illnesses. How concerning is it? Hint: It was necessary to provide an updated forecast.

T.A.C.T.
New research combining computer modeling and experiments with macaques shows the body’s #immune system helps control human #immunodeficiency virus (HIV) #infections largely by suppressing viral production in already infected cells while also killing #viral infected cells
#Biology #Virology #HIV #sflorg
https://www.sflorg.com/2023/10/bio10312301.html
Pinpointing HIV immune response

Refined understanding of T cells’ action in the body’s battle against the AIDS-causing virus will help improve treatments

There does not seem to be any rhyme or reason to when I feel well. So far, today is a good day. Yesterday was a very high pain day.

Results are still pending for the major autoimmune blood test and my theory is that it was positive so they had to run more tests.

I do have something called hypogammaglobulinemia which explains why I get sick so easily. Sigh. At least I never stopped masking.

https://en.m.wikipedia.org/wiki/Hypogammaglobulinemia

#Today #ChronicPain #Immunodeficiency

Hypogammaglobulinemia - Wikipedia

Researchers explore how patients with a rare and severe #immunodeficiency were still able to defend themselves normally against #viruses, including #COVID-19
#Medical #Biology #Virology #sflorg
https://www.sflorg.com/2023/05/med05082302.html
Study sheds light on how the immune system protects the body

Researchers explore how patients with a rare and severe immunodeficiency were still able to defend themselves normally against viruses, including COVI

A new UCLA-led study suggests that advanced #genome #editing #technology could be used as a one-time treatment for the rare and deadly genetic #disease #CD3 delta severe combined #immunodeficiency.
#Medical #Biology #sflorg #Science
https://www.sflorg.com/2023/03/med03212301.html
UCLA-led study uses base editing to correct mutation that causes rare immune deficiency

Advanced genome editing technology