🧠 New paper by Carneiro-Nascimento et al: awake #invivo #2p #CalciumImaging reveals diverse #CalciumDynamics in #meningeal #macrophages during cortical spreading depolarization (CSD), an aberrant #brain #hyperexcitability event linked to #migraine, #stroke, and #traumatic brain injury.

📝 https://doi.org/10.7554/eLife.109888

#Neuroimmunology #Neuroscience #imaging @eLife https://fediscience.org/@eLife/116605475951455191

"In light of the known deficiencies in #glutamate and potassium uptake by HD astrocytes, these findings suggest the potential for leakage of excitatory #synaptic contents during neurotransmission, and hence a structural basis for neuronal hyperexcitability in HD. More broadly, our data suggest that astrocytic structural #pathology may causally contribute to those #neurodegenerative disorders associated with central #hyperexcitability."

#asyrocyte #neurodegeneration

https://www.pnas.org/doi/10.1073/pnas.2210719120