Fabrizio MusacchioMay 20
🧠New paper by Carneiro-Nascimento et al: awake #invivo #2p #CalciumImaging reveals diverse #CalciumDynamics in #meningeal #macrophages during cortical spreading depolarization (CSD), an aberrant #brain #hyperexcitability event linked to #migraine, #stroke, and #traumatic brain injury. #Neuroscience

Intravital calcium imaging of ...
Intravital calcium imaging of meningeal macrophages reveals niche-specific dynamics and aberrant responses to brain hyperexcitability

Intravital microscopy of meningeal macrophage Ca²⁺ dynamics reveals previously unknown population heterogeneity, vasomotion-coupled activity, and diverse responses during steady state and neuroinflammatory conditions, offering relevant insights into brain immune regulation.

eLife
Fabrizio MusacchioMay 20

🧠 New paper by Carneiro-Nascimento et al: awake #invivo #2p #CalciumImaging reveals diverse #CalciumDynamics in #meningeal #macrophages during cortical spreading depolarization (CSD), an aberrant #brain #hyperexcitability event linked to #migraine, #stroke, and #traumatic brain injury.

📝 https://doi.org/10.7554/eLife.109888

#Neuroimmunology #Neuroscience #imaging @eLife https://fediscience.org/@eLife/116605475951455191

Fabrizio MusacchioSep 4, 2025

🧠 Pastorelli et al. (2025) present a "simplified two-compartment #neuron with #CalciumDynamics capturing #brain-state-specific apical-amplification, -isolation and -drive". This Ca-#AdEx model replicates distinct #dendritic mechanisms across wakefulness, #NREM & #REM sleep using a compact ThetaPlanes transfer function. Cool implementation using the #NESTsimulator 💻!

🌍 https://doi.org/10.3389/fncom.2025.1566196

#Neuroscience #CompNeuro