katch wreck"In light of the known deficiencies in #glutamate and potassium uptake by HD astrocytes, these findings suggest the potential for leakage of excitatory #synaptic contents during neurotransmission, and hence a structural basis for neuronal hyperexcitability in HD. More broadly, our data suggest that astrocytic structural #pathology may causally contribute to those #neurodegenerative disorders associated with central #hyperexcitability."