Bluesky

Bluesky

Webinar: Filamentous bacteria

Webinar: Filamentous bacteria

A searchable image resource of Drosophila GAL4 driver expression patterns with single neuron resolution

Single neuron images of Drosophila driver lines reveal neuron shape and are searchable, enabling comparisons to electron microscopy and prediction of intersectional neuron targeting strategies.

Major advance in super-resolution fluorescence microscopy

Scientists led by Nobel Laureate Stefan Hell at the Max Planck Institute for Medical Research in Heidelberg have developed a super-resolution microscope with a spatio-temporal precision of one nanometer per millisecond. An improved version of their recently introduced MINFLUX super-resolution microscopy allowed tiny movements of single proteins to be observed at an unprecedented level of detail: the stepping motion of the motor protein kinesin-1 as it walks along microtubules while consuming ATP. The work, published in Science, highlights the power of MINFLUX as a revolutionary new tool for observing nanometer-sized conformational changes in proteins.