Giuseppe MichieliDec 19, 2024
Revealing novel #CD8+ T-cell #epitopes from the #H5N1 avian #influenza virus in HBW/B1 haplotype #ducks, https://etidiohnew.blogspot.com/2024/12/revealing-novel-cd8-t-cell-epitopes.html
Revealing novel #CD8+ T-cell #epitopes from the #H5N1 avian #influenza virus in HBW/B1 haplotype #ducks

Giuseppe MichieliMay 12, 2024

#Epitopes in the #HA and #NA of #H5 and #H7 avian #influenza viruses that are important for #antigenic #drift, FEMS Microbiol Rev.: https://academic.oup.com/femsre/advance-article/doi/10.1093/femsre/fuae014/7670612?login=false

This review aims to compile the current information on haemagglutinin and #neuraminidase epitopes and immune escape mutants of H5 and H7 highly pathogenic avian influenza viruses.

Epitopes in the HA and NA of H5 and H7 avian influenza viruses that are important for antigenic drift

Abstract. Avian influenza viruses evolve antigenically to evade host immunity. Two influenza A virus surface glycoproteins, the haemagglutinin and neuramin

OUP Academic
Giuseppe MichieliMay 2, 2024

Characteristics of #epitopes of limited variability on the head of #influenza #H1 #haemagglutinin http://biorxiv.org/cgi/content/short/2024.04.30.591841v1?rss=1

We conclude that the variability of an antibody binding site is determined by the number of variable residues included in its footprint rather than the intrinsic entropy of any particular region.

Giuseppe MichieliApr 16, 2024

#Epitopes of an #antibody that neutralizes a wide range of #SARS-CoV-2 #variants in a conserved subdomain 1 of the #spike protein, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00416-24?af=R

Demonstrated identification of the neutralizing antibody that recognizes a conserved epitope implies basal contribution of such group of antibodies for #prophylaxis against #COVID19.

PLOS BiologyDec 12, 2023
Multiplexed #CellularImaging. @DdJB_neuro @MohsenSadeghi &co label individual proteins with nanobarcodes comprising combinations of multiple #epitopes, allowing a normal 4-channel microscope to reveal identities of up to 15 different proteins #PLOSBiology https://plos.io/48bQ7G3
Protein nanobarcodes enable single-step multiplexed fluorescence imaging

Multiplexed cellular imaging typically relies on the sequential application of detection probes, which is complex and time-consuming. This study describes a novel approach to protein labeling, in which individual proteins are tagged with combinations of multiple epitopes. This allows a normal four-color-channel microscope to reveal identities of up to fifteen different proteins, enabling simple and powerful multiplexing.

CellBioNewsMay 26, 2023

'#Bioprospecting' technique uncovers #viruses that can kill deadly superbugs.

#phages #antimicrobial #epitopes #porin

https://phys.org/news/2023-05-bioprospecting-technique-uncovers-viruses-deadly.html

'Bioprospecting' technique uncovers viruses that can kill deadly superbugs

In a modern take on the Victorian gold rush, a Monash University-led project is successfully "bioprospecting" for viruses known as phages that can kill deadly superbugs.

La Jolla InstituteJan 11, 2023

New review from the Peters Lab at LJI: "T-cell epitope discovery and single-cell technologies to advance food allergy research"

As they write, "Advancements in single-cell T-cell receptor (TCR) sequencing in combination with transcriptome analysis provide exciting opportunities for identification and characterization of the TCR repertoires of allergen-specific T cells."

https://doi.org/10.1016/j.jaci.2022.10.025

#Tcells #FoodAllergy #Epitopes #Immunology #ImmuneSystem #CellularBiology #Genomics #OpenAccess

Liz WoodDec 19, 2022

Hurray!

Eli Weinstein, @andrenguyen and myself got a contributed talk accepted at Winter Q-Bio! #winterqbio #qbio

Reach out if you'd like to hear about our work estimating the effects of mutations across the T cell receptor on epitope binding using observational data. The same sequence based methods generalize to a number of settings, including #antibodies.

#tcell #mutation #sequences #epitopes #epitopebinding #cdr #cdr3 #tcr #bcr