Researchers reveal crucial role of #RNA in modulating #autophagic degradation of #protein condensates.
https://phys.org/news/2023-04-reveal-crucial-role-rna-modulating.html
A research group led by Prof. Zhang Hong from the Institute of Biophysics of the Chinese Academy of Sciences has demonstrated that RNAs act as a switch to change the fate of phase-separated protein condensates from autophagic degradation to stress-triggered accumulation. The study was published online in Journal of Cell Biology.
TFEB-dependent lysosome biogenesis is required for #senescence
by Bernadette Carroll and coworkers
Transcription factor #TFEB induces #lysosome proliferation in #senescent cells, counterbalancing reduced lysosomal efficiency and maintaining #autophagic capacity
https://www.embopress.org/doi/10.15252/embj.2022111241
A #protelysis cascade fine-tunes homologous #recombination repair in plants:
Arp Schnittger and coworkers show #KNOTEN1, stabilized by #UBP12/13, triggering K63-linked #ubiquitination and #autophagic degradation of #BLM complex subunit #RMI1 upon #DNAdamage
The EMBO Journal
CellBioNews