This brief highlights a mechanism with potential relevance for mental health care by illustrating how cellular processes influence brain function and neurodegenerative risk. Understanding how lysosomal regulation and waste processing relate to neural integrity can inform thinking about mood and cognition in aging populations, as well as the broader context of neurodegenerative risk factors that may intersect with mental health presentations. The described discovery of TMEM175 as a regulator of lysosomal acidity points to a tangible biological target that could, in the long run, shape therapeutic directions for clinicians who work with patients affected by neurodegenerative and neuropsychiatric symptoms.

Article Title: Scientists discover “overflow valve” in cells linked to Parkinson’s Disease

Link to Science Daily Mind-Brain News: https://www dot sciencedaily dot com/releases/2026/03/260325005920 dot htm

Scientists discover “overflow valve” in cells linked to Parkinson’s Disease
https://www dot sciencedaily dot com/releases/2026/03/260325005920 dot htm
Researchers have identified a crucial ion channel, TMEM175, that acts like an overflow valve in the cell’s recycling system. It regulates acidity inside lysosomes, ensuring they function properly. When TMEM175 is faulty, toxic buildup can occur, contributing to diseases like Parkinson’s. This breakthrough reveals a promising new target for future therapies.
via Mind & Brain News -- ScienceDaily https://www dot sciencedaily dot com/news/mind_brain/
March 26, 2026 at 07:35AM

#neurodegeneration #ParkinsonsResearch #lysosome #TMEM175 #neurobiology

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Postdoc, PhD, Master
Ebner lab

Join the Ebner lab to discover lysosomal lipid logistics pathways

See the full job description on jobRxiv: https://jobrxiv.org/job/ebner-lab-27778-postdoc-phd-master/

#battendisease #lipidtransport #lysosome #membranecontactsites #microglia #microscopy #neurodegeneration #repair #ScienceJobs #hiring #research
https://jobrxiv.org/job/ebner-lab-27778-postdoc-phd-master/?fsp_sid=4848

Postdoc, PhD, Master
Ebner lab

Join the Ebner lab to discover lysosomal lipid logistics pathways

See the full job description on jobRxiv: https://jobrxiv.org/job/ebner-lab-27778-postdoc-phd-master/

#battendisease #lipidtransport #lysosome #membranecontactsites #microglia #microscopy #neurodegeneration #repair #ScienceJobs #hiring #research
https://jobrxiv.org/job/ebner-lab-27778-postdoc-phd-master/?fsp_sid=3455

Postdoc, PhD, Master
Ebner lab

Join the Ebner lab to discover lysosomal lipid logistics pathways

See the full job description on jobRxiv: https://jobrxiv.org/job/ebner-lab-27778-postdoc-phd-master/

#battendisease #lipidtransport #lysosome #membranecontactsites #microglia #microscopy #neurodegeneration #repair #ScienceJobs #hiring #research
https://jobrxiv.org/job/ebner-lab-27778-postdoc-phd-master/?fsp_sid=1096

Postdoc, PhD, Master
Ebner lab

Join the Ebner lab to discover lysosomal lipid logistics pathways

See the full job description on jobRxiv: https://jobrxiv.org/job/ebner-lab-27778-postdoc-phd-master/

#battendisease #lipidtransport #lysosome #membranecontactsites #microglia #microscopy #neurodegeneration #repair #ScienceJobs #hiring #research
https://jobrxiv.org/job/ebner-lab-27778-postdoc-phd-master/?fsp_sid=39

Focus sur la Maladie de #Parkinson sans mutation :

2 mécanismes de progression distinctes = 2 dysfonctionnements cellulaires.
-> la #mitochondrie : structure cellulaire générant l'énergie nécessaire aux cellules = aspects moteurs.
-> le #lysosome : organite cellulaire effectuant la digestion intracellulaire = troubles cognitifs #cerveau

cf https://mastodon.social/@cobrate/114166007687595849

#science #sante

Uncovering the Ancient Origins of Key Immune Machinery https://www.ualberta.ca/en/department-of-medicine/news-events/department-news/2024/10/joel-dacks-uncovering-the-ancient-origins-of-key-immune-machinery.html

Evolutionary origins of the #lysosome-related #organelle sorting machinery reveal ancient homology in post-#endosome trafficking pathways: Kiran More et al. https://www.pnas.org/doi/10.1073/pnas.2403601121

"the BLOC machinery plays an important role in #microbes today for our ecosystem and health and may help to explain the #evolution of the basic cellular configuration over 1.5 billion years ago."

#Protists #ImmuneSystem #Eukaryogenesis

"Our study demonstrates a unique role for MANF in autophagy and lysosome function, critical processes for clearing toxic proteins. In the animal model Caenorhabditis elegans, overexpressing MANF extended lifespan, reduced protein clumps, and conferred protection on neurons. These roles of MANF are mediated by the HLH-30/TFEB, a master regulator of lysosome function"

https://www.pnas.org/doi/10.1073/pnas.2403906121

#autophagy #neuron #aging #lysosome #biology

LAMP1 protein-tracking with clever use of proximity labeling reveals neuron-specific Lysosomal function.

Spatiotemporal proteomics reveals the biosynthetic lysosomal membrane protein interactome in neurons
Li et al., preprint at biorxiv 2024
https://www.biorxiv.org/content/10.1101/2024.05.16.594502v1?ct=

#preprint #neuroscience #proteomics #lysosome