Daniel Hoffmann 🌼Killing #senescent cells (damaged cells that don't die) rejuvenates mice spectacularly. Now a study with fast #ageing childhood cancer survivors tests this in humans. https://www.theguardian.com/science/2025/feb/08/anti-ageing-jabs-they-can-rejuvenate-mice-but-will-they-work-on-humans
Prolonged use of energy rich "Western" diet can (in mice) revive #senescent #liver cells to #cancer cells. https://www.nature.com/articles/d41586-024-04137-z
Scientific Frontline#Senescent cells have been implicated in a variety of processes typically connected with #deterioration and #aging. Recent studies suggest that the short-term presence of senescent cells can actually be beneficial.
#Biology #sflorg
https://www.sflorg.com/2023/10/bio10272301.html
#Biology #sflorg
https://www.sflorg.com/2023/10/bio10272301.html
UnivGroJobs (By: Jako Jellema)#PhD student studying #pathological
#senescence
Salary:
€ 2.789 - € 3.536 #PhDposition
"We are looking for an enthusiastic and ambitious PhD candidate in the Laboratory of Cellular senescence and age-related pathologies, headed by Prof. Marco Demaria to work on a project studying the contribution of #senescent cells to inflammatory and #fibrotic chronic disease. "
Required : MSc in #Biology
Closing date: August 24 CET
#UMCGroningen #UMCG #Groningen
https://werkenbijumcg.nl/-/vacatures/phd-student-studying-pathological-senescence/10419-02s00088pp
PLOS Biology#TissueDamage induces spatially distinct patterns of #senescent & #proliferative cell behaviors; this allocates distinct cellular tasks required for tissue repair, driven by mutual repression between JNK/AP-1 & JAK/STAT signaling @classenlab #PLOSBiology https://plos.io/43dDU1z
Mutual repression between JNK/AP-1 and JAK/STAT stratifies senescent and proliferative cell behaviors during tissue regeneration
This study shows that tissue damage induces spatially distinct patterns of senescent and proliferative cell behaviors; this spatial separation allocates distinct cellular tasks that are required for tissue repair and is driven by mutual repression between JNK/AP-1 and JAK/STAT signaling.
Justin D Kruger (he/him)Benefits of 'zombie' cells: Senescent cells aid regeneration in salamanders.
https://phys.org/news/2023-04-benefits-zombie-cells-senescent-aid.html
#news #senescent #longevity #aging
Benefits of 'zombie' cells: Senescent cells aid regeneration in salamanders
Senescent cells, often referred to as "zombie" cells, have long been associated with aging and disease. However, a new study from the Center for Regenerative Therapies Dresden (CRTD) at TU Dresden adds to a growing body of evidence that not all senescent cells are harmful.
CellBioNewsBenefits of 'zombie' cells: #Senescent #cells aid #regeneration in #salamanders.
https://phys.org/news/2023-04-benefits-zombie-cells-senescent-aid.html
Benefits of 'zombie' cells: Senescent cells aid regeneration in salamanders
Senescent cells, often referred to as "zombie" cells, have long been associated with aging and disease. However, a new study from the Center for Regenerative Therapies Dresden (CRTD) at TU Dresden adds to a growing body of evidence that not all senescent cells are harmful.
#Scientists show that so-called #senescent #cells, i.e., cells that have permanently stopped dividing, boost production of new #muscle cells to enhance regeneration of lost limbs in #salamanders. (#Zombie cells)
#Biology #sflorg
https://www.sflorg.com/2023/04/bio04142301.html
#Biology #sflorg
https://www.sflorg.com/2023/04/bio04142301.html
From yeast to mice, from mice to man: #Senescent #cells get noisier with #age.
https://phys.org/news/2023-04-yeast-mice-senescent-cells-noisier.html
From yeast to mice, from mice to man: Senescent cells get noisier with age
Getting old seems completely avoidable in youth but becomes less and less so as we age. Many of the obstacles of advanced aging are well understood, including declining eyesight, hearing loss, back, neck and arthritic joint pains, shortness of breath, diabetes, Alzheimer's disease, dementia, cancer and stroke, just to name a few. What is less understood are the cellular-level molecular mechanisms responsible for our overall decline.
The EMBO JournalTFEB-dependent lysosome biogenesis is required for #senescence
by Bernadette Carroll and coworkers
Transcription factor #TFEB induces #lysosome proliferation in #senescent cells, counterbalancing reduced lysosomal efficiency and maintaining #autophagic capacity
https://www.embopress.org/doi/10.15252/embj.2022111241