That session was concluded by Caroline Hochheuser showing our own #scRNAseq work, comparing primary #tumour to bone marrow #metastasis from the same patients. π€©
An additional parallel session, also several presentations on heterogeneity: in a relapse model - great to see the work of Ellen Westerhout again. Focused on different drug sensitivities of #adrenergic and #mesenchymal cells. And another one by JΓΆrg Otte, focusing on SCP-like cells, using some tools I need to check out, like #Numbat, https://github.com/kharchenkolab/numbat/ #rstats
Yesterday, in the afternoon plenty of #scRNAseq work, a.o. CΓ©line Delloye-Bourgeois showing her group's latest work on #neuroblastoma development and #metastatic progression. Including some of our own scRNA-seq data. Very cool.
Furthermore, more #SingleCell, also spatial, sequencing on #tumour heterogeneity and early stages. And work on cells that persist during/after #therapy, dubbed persister cells.
An impressive keynote lecture by Chris Marine on #melanoma and the role of the #tumour #microenvironment, and MES-like cells in #metastasis and #drug #resistance.
Further presentations on #MYCN binding not just DNA but also RNA, #MKK7 mutations in high risk #neuroblastoma, #BARD1 mutations,
DNA damage repair deficiency incl. enhanced #metastasis.
Plus 1 minute pitches for posters, including a #poem. π
Arjan Boltjes