Mastodawn

One molecule could reverse aging, boost memory, and repair muscle
Imagine a pill that could slow aging, sharpen your memory, strengthen muscles, and reduce chronic inflammation. It sounds like science fiction, but scientists have discovered a molecule that could make this dream a reality. This molecule activates TERT, a key enzyme that protects DNA as we age. In lab tests, it didn’t just slow aging—it reversed many signs of it.

In studies with older models, six months of treatment with this TERT-activating compound (TAC) triggered new brain cell growth, improved genes related to memory, and reduced inflammation. It also cleared out damaged “zombie” cells, which are linked to aging, and restored muscle strength and coordination. In human cells, TAC helped cells divide longer by lowering DNA damage, essentially promoting healthier aging.

This breakthrough holds massive potential for age-related diseases like Alzheimer’s, Parkinson’s, heart disease, and cancer. While it’s still in the early stages, the possibility of reversing aging itself could soon be within our grasp.
The idea of stopping or even reversing the aging process is no longer just a fantasy. Thanks to this discovery, the future of medicine might be closer than we think.

Longevity & anti-aging
#Longevity #HealthyAging #ReversingAging #LifeExtension #AgeReversal

Molecular & cellular science
#TERT #Telomerase #CellularSenescence #MolecularBiology #DNARepair

Brain & muscle health
#Neurogenesis #BrainHealth #MuscleRegeneration #CognitiveHealth

Innovation & medicine
#MedicalBreakthrough #Biotech #RegenerativeMedicine #FutureOfMedicine

Universität zu Köln Oct 4, 2024

🔬🫁 New Study on Rare Lung Tumors🧬🩺

Researchers at the University of Cologne an University Hospital have discovered that TERT gene activation is crucial for the progression of rare lung tumors (pulmonary carcinoids). This gene activation determines whether the tumor remains benign or becomes aggressive and spreads.

Learn more ➡️ https://uni.koeln/42W9Y

The paper was published in Journal of Clinical Oncology ➡️
https://ascopubs.org/doi/pdf/10.1200/JCO.23.02708

#UniCologne #TERT #Research #LungTumor #CancerResearch

Rare lung cancer: gene activation determines mild or aggressive course

Researchers from the University of Cologne and University Hospital Cologne have discovered key factors that determine different disease progressions in rare lung tumours / publication in the ‘Journal of Clinical Oncology’

Ben Werdmuller Aug 20, 2023

This #CRISPR result - an HIV-like virus was eradicated from non-human primates - is encouraging. I also have a strong, selfish interest in seeing it used as a treatment for genetic conditions like the #TERT #pulmonaryfibrosis mutation that runs in my family. https://www.nature.com/articles/s41434-023-00410-4

Preclinical safety and biodistribution of CRISPR targeting SIV in non-human primates - Gene Therapy

In this study, we demonstrate the safety and utility of CRISPR-Cas9 gene editing technology for in vivo editing of proviral DNA in ART-treated, virally controlled simian immunodeficiency virus (SIV) infected rhesus macaques, an established model for HIV infection. EBT-001 is an AAV9-based vector delivering SaCas9 and dual guide RNAs designed to target multiple regions of the SIV genome: the viral LTRs, and the Gag gene. The results presented here demonstrate that a single IV inoculation of EBT-001 at each of 3 dose levels (1.4 × 1012, 1.4 × 1013 and 1.4 × 1014 genome copies/kg) resulted in broad and functional biodistribution of AAV9-EBT-001 to known tissue reservoirs of SIV. No off-target effects or abnormal pathology were observed, and animals returned to their normal body weight after receiving EBT-001. Importantly, the macaques that received the 2 highest doses of EBT-001 showed improved absolute lymphocyte counts as compared to antiretroviral-treated controls. Taken together, these results demonstrate safety, biodistribution, and in vivo proviral DNA editing following IV administration of EBT-001, supporting the further development of CRISPR-based gene editing as a potential therapeutic approach for HIV in humans.

Nature

Arjan Boltjes May 15, 2023

The Advances Neuroblastoma Research meeting #anr2023 has kicked off, Lisa Werr showing the role of #telomerase / #TERT in #neuroblastoma in mice and humans in the first talk.

Jared Stevens Nov 22, 2022

Spent the day getting ready for thanksgiving. It was pretty cold today. I am already starting to miss summer. Local mountains here have goats all over them. This guy let me get close enough to snap this with my longest zoom.
#goats #photography #timpanogos #tert