One molecule could reverse aging, boost memory, and repair muscle
Imagine a pill that could slow aging, sharpen your memory, strengthen muscles, and reduce chronic inflammation. It sounds like science fiction, but scientists have discovered a molecule that could make this dream a reality. This molecule activates TERT, a key enzyme that protects DNA as we age. In lab tests, it didn’t just slow aging—it reversed many signs of it.

In studies with older models, six months of treatment with this TERT-activating compound (TAC) triggered new brain cell growth, improved genes related to memory, and reduced inflammation. It also cleared out damaged “zombie” cells, which are linked to aging, and restored muscle strength and coordination. In human cells, TAC helped cells divide longer by lowering DNA damage, essentially promoting healthier aging.

This breakthrough holds massive potential for age-related diseases like Alzheimer’s, Parkinson’s, heart disease, and cancer. While it’s still in the early stages, the possibility of reversing aging itself could soon be within our grasp.
The idea of stopping or even reversing the aging process is no longer just a fantasy. Thanks to this discovery, the future of medicine might be closer than we think.

Longevity & anti-aging
#Longevity #HealthyAging #ReversingAging #LifeExtension #AgeReversal

Molecular & cellular science
#TERT #Telomerase #CellularSenescence #MolecularBiology #DNARepair

Brain & muscle health
#Neurogenesis #BrainHealth #MuscleRegeneration #CognitiveHealth

Innovation & medicine
#MedicalBreakthrough #Biotech #RegenerativeMedicine #FutureOfMedicine

Vitamin D May Help Slow Aging, Study Finds

Could a simple vitamin help slow the ticking of our biological clocks? A new study suggests vitamin D may protect the delicate chromosome caps linked to aging, potentially lowering the risk of age-related diseases. Credit: Stock A clinical trial suggests vitamin …
#dining #cooking #diet #food #Nutrition #aging #longevity #nutrition #Telomerase #TheConversation #Vitamins
https://www.diningandcooking.com/2283295/vitamin-d-may-help-slow-aging-study-finds/

Study reveals how #cells keep #telomerase in check.

#ATR_kinase #CRISPR #DNA_breaks

https://phys.org/news/2024-02-reveals-cells-telomerase.html

"Unexpectedly, approximately 15% of the steady state population of hTR has a CR4/5 conformation lacking features required for hTERT binding. Mutagenesis demonstrates that stabilization of the alternative CR4/5 conformation is detrimental to telomerase assembly and activity. We propose that this misfolded portion of the cellular hTR pool is either slowly refolded or degraded."

#Preprint #Telomeres #Telomerase

https://www.biorxiv.org/content/10.1101/2023.10.04.560962v1

Watching Makers of Modern #Australia

#DavidUnaipon
#VeenaSahajwalla #circulareconomy #ElizabethBlackburn #Telomerase
#FionaWood #sprayonskin #FionaStanley #Folate #B9 #BlackBox #solarcell #Cochlearimplant

https://iview.abc.net.au/video/DO2128H002S00

90% of cancers reactivate telomerase. In our new preprint, we reveal that tumors that fail to activate telomerase trigger a stronger immune response, leading to melanoma regression. Our work also sheds light on the association between telomerase gene mutations and the immune system and provide a mechanism to explore the success of immunotherapies. 🐟 #zebrafish 🧬#telomerase 💊#immunotherapy 🔬#cancerresearch

https://www.biorxiv.org/content/10.1101/2023.03.24.534079v1

'To study TERT deregulation and its downstream consequences, we generated a Tert mutant promoter mouse model via CRISPR/Cas9 engineering of the murine equivalent locus (Tert-123C>T) and crossed it with thyroid-specific BrafV600E-mutant mice.'

#Preprint #Telomeres #telomerase

https://www.biorxiv.org/content/10.1101/2023.01.24.525280v1?med=mas