Victoria Stuart 🇨🇦 🏳️‍⚧️Apr 17, 2025

Adipose tissue retains epigenetic memory of obesity after weight loss
https://www.nature.com/articles/s41586-024-08165-7
https://news.ycombinator.com/item?id=43678138

* may prime cells for pathological responses in obesogenic environment contributing to problematic yo-yo effect seen w. dieting

#obesity #epigenetics #adipocytes

Adipose tissue retains an epigenetic memory of obesity after weight loss - Nature

Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to the problematic ‘yo-yo’ effect often seen with dieting.

Nature
PLOS BiologyDec 6, 2023
#BrownAdiposeTissue is mostly found in the supraclavicular region, but where does it come from? @RuanLab show that supraclavicular brown #adipocytes are derived from a group of Tbx1+ myogenic progenitors, distinct from Myf5-expressing cells #PLOSBiology https://plos.io/47LJASA
Supraclavicular brown adipocytes originate from Tbx1+ myoprogenitors

Brown adipose tissue (BAT) dissipates energy as heat, contributing to temperature control, energy expenditure, and systemic homeostasis. In adult humans, BAT mainly exists in supraclavicular areas and its prevalence is associated with cardiometabolic health. However, the developmental origin of supraclavicular BAT remains unknown. Here, using genetic cell marking in mice, we demonstrate that supraclavicular brown adipocytes do not develop from the Pax3+/Myf5+ epaxial dermomyotome that gives rises to interscapular BAT (iBAT). Instead, the Tbx1+ lineage that specifies the pharyngeal mesoderm marks the majority of supraclavicular brown adipocytes. Tbx1Cre-mediated ablation of peroxisome proliferator-activated receptor gamma (PPARγ) or PR/SET Domain 16 (PRDM16), components of the transcriptional complex for brown fat determination, leads to supraclavicular BAT paucity or dysfunction, thus rendering mice more sensitive to cold exposure. Moreover, human deep neck BAT expresses higher levels of the TBX1 gene than subcutaneous neck white adipocytes. Taken together, our observations reveal location-specific developmental origins of BAT depots and call attention to Tbx1+ lineage cells when investigating human relevant supraclavicular BAT.

Stephen Matheson🌵🌲Aug 30, 2023

Second half of the "variation and information" session #CSSingleCells23
led off by Sam Morris of WashU
http://morrislab.wustl.edu/

Multi-omic lineage tracing: insights into reprogramming cell identity

her piece in *Development*, "The evolving concept of cell identity in the single cell era"

working on "induced hepatocytes", start with fibroblasts, via "induced endoderm progenitors"

new work on #adipocytes
https://www.biorxiv.org/content/10.1101/2023.06.01.543318v1

#reprogramming
#StemCells
#CellIdentity
#CellFate

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Samantha Morris Lab

The Morris Lab is a stem cell and developmental biology laboratory based in the Departments of Genetics, and Developmental Biology at Washington University in St. Louis, USA. Our research focuses on dissecting the gene regulatory networks that define cell fate. We apply this knowledge to engineer clinically relevant cell types.

Seth Thomas ScanlonMar 31, 2023

Also in @sciencemagazine this week: Giuseppe Matarese pens a Perspective on the link between #obesity and #autoimmunity!

https://bit.ly/Sci_ade0113

#immunometabolism #overnutrition #T1D #MS #Tregs #adipocytes #CaloricRestriction #immunotherapy

Matthew SintonDec 18, 2022
Updated #introduction time. I’m a postdoctoral research associate at the University of Glasgow, interested in energy homeostasis and sickness behaviour 
Research interests include #adipocytes #adiposetissue #metabolism #immunometabolism #immunity and #IL-17 ! 
I also founded The STEM Village, an initiative to promote visibility of #LGBTQ people in #STEM 🏳️‍🌈🏳️‍⚧️🏳️‍🌈🏳️‍⚧️🏳️‍🌈🏳️‍⚧️ you can find out more on our website https://www.thestemvillage.com or our #YouTube channel https://youtube.com/@thestemvillage3092
Improving LGBTQ+ Visibility in STEM | The STEM VIllage

Welcome to The STEM Village. The STEM Village is a space dedicated to increasing visibility of the LGBTQ+ community in science, technology, engineering and maths (STEM). We aim to showcase the work of the LGBTQ+ STEM community and inspire LGBTQ+ people who are thinking about joining STEM fields

The STEM Village
Matthew SintonNov 18, 2022
#Introduction time. I’m a postdoctoral research associate at the University of Glasgow
Research interests include #adipocytes #adiposetissue #metabolism #immunometabolism #immunity and #IL-17 ! 
I also founded The STEM Village, an initiative to promote visibility of #LGBTQ people in #STEM 🏳️‍🌈🏳️‍⚧️🏳️‍🌈🏳️‍⚧️🏳️‍🌈🏳️‍⚧️ you can find out more on our website https://www.thestemvillage.com or our #YouTube channel https://youtube.com/channel/UCULuHvpzPgU2SDd0unWAMCw
Improving LGBTQ+ Visibility in STEM | The STEM VIllage

Welcome to The STEM Village. The STEM Village is a space dedicated to increasing visibility of the LGBTQ+ community in science, technology, engineering and maths (STEM). We aim to showcase the work of the LGBTQ+ STEM community and inspire LGBTQ+ people who are thinking about joining STEM fields

The STEM Village