Mastodawn

🫘 Caffeine blocks adenosine, the same pathway used by fast-acting depression treatments

https://medicalxpress.com/news/2025-11-caffeine-blocks-adenosine-pathway-fast.html

#caffeine #brain #neuroscience #depression #antidepressants #pharmacology #adenosine

Caffeine blocks adenosine, the same pathway used by fast-acting depression treatments

Perhaps the most intriguing implication of recent breakthrough research lies in an unexpected connection: the most rigorous mechanistic dissection of rapid antidepressant action identifies adenosine as the critical mediator, yet adenosine receptors are the primary target of caffeine, the world's most widely consumed psychoactive substance.

Medical Xpress

N-gated Hacker News Dec 6

🚨BREAKING🚨: #Coffee somehow linked to #antidepressants because... adenosine? 🤔 Apparently, #caffeine is the underdog hero in saving our brains, but don't worry, the article has made it as clear as mud. ☕️+🧠=🤷‍♂️ #ScientificAlchemy
https://genomicpress.kglmeridian.com/view/journals/brainmed/aop/article-10.61373-bm025c.0134/article-10.61373-bm025c.0134.xml #Adenosine #BrainHealth #HackerNews #ngated

Adenosine as the metabolic common path of rapid antidepressant action: The coffee paradox

Genomic Press

Hacker News Dec 6

Adenosine on the common path of rapid antidepressant action: The coffee paradox

https://genomicpress.kglmeridian.com/view/journals/brainmed/aop/article-10.61373-bm025c.0134/article-10.61373-bm025c.0134.xml

#HackerNews #Adenosine #Coffee #Antidepressants #Research #MentalHealth

Adenosine as the metabolic common path of rapid antidepressant action: The coffee paradox

Genomic Press

News Beep Nov 14

Study finds brain may remember best when tired, suggesting fatigue can boost learning

Turns out, your brain might actually remember things better when it’s running low on energy. Researchers at Japan’s…
#NewsBeep #News #Headlines #adenosine #brainmemory #fatigue #Latvia #learning #long-termpotentiation #LV
https://www.newsbeep.com/249116/

IFR (she/her)Apr 22, 2025

Obs done, ECG done, appointment with cardiac specialist nurse done, consent form signed.

Just waiting for bloods now, then it’s back tomorrow morning as an inpatient for some #adenosine and to see how broken my heart is.

adacosta Oct 4, 2024

Had trouble #sleeping last night, so having a cup of #coffee which I don't really like drinking. My #adenosine is not happy. https://www.youtube.com/watch?v=gzLPa6NbcrE

Why you’re so tired

Why You’re So TiredCheck out https://ground.news/johnnyharris to see how any news story is being framed by news outlets around the world and across the polit...

YouTube

CellBioNews Aug 4, 2024

Researchers elucidate mechanisms behind #protein selectivity in #adenosine #receptor.

#G_protein #A_2A_R #signalling

https://phys.org/news/2024-08-elucidate-mechanisms-protein-adenosine-receptor.html

Researchers elucidate mechanisms behind protein selectivity in adenosine receptor

In a new study, a multinational research team led by Dr. Adnan Sljoka (RIKEN) and Prof. Akio Kitao (Tokyo Tech), in collaboration with Prof. Scott Prosser (University of Toronto), has carried out experimental and computational studies to elucidate the mechanisms behind G protein selectivity and efficacy in the human adenosine A2A receptor (A2AR).

Phys.org

🐦‍🔥nemo™🐦‍⬛ 🇺🇦🍉Oct 17, 2023

#funfact

#Caffeine can #cause #psychosis in some #cases Caffeine is a competitive #adenosine #antagonist that #affects #dopamine #transmission and has been #reported to #worsen #psychosis in people with #schizophrenia and to cause psychosis in #otherwise #Healthy #people. It can even be used to #induce #modelpsychosis

https://pubmed.ncbi.nlm.nih.gov/19407709/

https://jaapl.org/content/early/2020/05/13/JAAPL.003923-20

https://www.psychologytoday.com/us/blog/the-science-mental-health/202006/can-caffeine-induce-psychosis

https://www.cambridge.org/core/journals/advances-in-psychiatric-treatment/article/neuropsychiatric-effects-of-caffeine/7C884B2106D772F02DA114C1B75D4EBF

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770234/

#openacces
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/06205615C031CA29B18F8C886EF08E7C/S2056472421005056a.pdf/div-class-title-the-path-is-smooth-that-leadeth-on-to-danger-caffeine-and-psychosis-div.pdf

Caffeine-induced psychosis - PubMed

As a competitive adenosine antagonist, caffeine affects dopamine transmission and has been reported to worsen psychosis in people with schizophrenia and to cause psychosis in otherwise healthy people. We report of case of apparent chronic caffeine-induced psychosis characterized by delusions and par …

PubMed