Researchers elucidate mechanisms behind protein selectivity in adenosine receptor

In a new study, a multinational research team led by Dr. Adnan Sljoka (RIKEN) and Prof. Akio Kitao (Tokyo Tech), in collaboration with Prof. Scott Prosser (University of Toronto), has carried out experimental and computational studies to elucidate the mechanisms behind G protein selectivity and efficacy in the human adenosine A2A receptor (A2AR).

Phys.org
How a calcium-sensing protein multitasks

The calcium-sensing receptor is critical for maintaining healthy calcium levels, but CaSR is also well-known for its side hustles. The receptor is increasingly recognized for its ability to detect other ions and proteins and for its role in breast cancer, heart disease, diabetes, and other conditions, making it an important drug target for multiple diseases.

Phys.org