ScienceOpenAug 7, 2025

'Single-cell sequencing reveals the expansion and diversity of T cell subsets in the bone marrow microenvironment of chronic myeloid leukemia' - a Genes & Diseases article on #ScienceOpen:

🔎 https://www.scienceopen.com/document?vid=a1a783a1-5180-487b-b736-d5d814a5fb75

#CancerImmunology #LeukemiaResearch #TCells #SingleCellSequencing

Single-cell sequencing reveals the expansion and diversity of T cell subsets in the bone marrow microenvironment of chronic myeloid leukemia

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d9200406e246">The immune microenvironment plays an important role in leukemia treatment. However, a specific single-cell profiling of the immune alteration in bone marrow of chronic myeloid leukemia (CML) patients is still lacking. We performed multi-level single-cell sequencing to systematically decipher the bone marrow T cell atlas of CML patients. The results exhibited extensive changes of T cells, including the decreased CD4 T cells and increased CD8 T cells in the CML bone marrow. Subpopulation analysis revealed a significant increase of CD8 terminal effector (TE) cells and a significant decrease of CD4 naïve T cells. T cell receptor sequencing showed that the overall diversity of the T cell receptor repertoire was reduced in CML, with the exception of the CD8 TE cell. In addition, CD8 TE cells were the main source of gene expression differences in CD8 T cells. Intercellular communication analysis revealed the altered interaction between CD8 TE and other non-T cells in CML, including neutrophil subtype, indicating the potential regulation of bone marrow microenvironment cells on CD8 TE dynamics. Collectively, our work characterises the alteration of T cell subsets in CML patients at multiple single-cell levels, providing a valuable resource for understanding the immune microenvironment and developing new immune strategies for CML therapy. </p>

ScienceOpen
jobRxivAug 10, 2023

Research technician

University of Manitoba

Are you interested in using novel single cell technologies to understand the inner ear? Come join our team!

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-manitoba-27778-research-technician/?feed_id=54539

#ScienceJobs #hiring #research #singlecellsequencing #genomics @um_bmg
Winnipeg #Canada #ResearchTechnician
https://jobrxiv.org/job/university-of-manitoba-27778-research-technician/?feed_id=54539

Research technician

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jobRxiv
jobRxivJan 15, 2023

Postdoc: interpretable deep learning to analyse single-cell data @molina_lab

https://jobrxiv.org/job/igbmc-27778-postdoc-interpretable-deep-learning-to-analyse-single-cell-data/?feed_id=34334

#ScienceJobs #Bioinformatics,#SingleCellSequencing,#DeepLearning
Strasbourg #France #Bioinformatician #PostdoctoralFellow
https://jobrxiv.org/job/igbmc-27778-postdoc-interpretable-deep-learning-to-analyse-single-cell-data/?feed_id=34334

jobRxivDec 26, 2022

Postdoc: interpretable deep learning to analyse single-cell data @molina_lab

https://jobrxiv.org/job/igbmc-27778-postdoc-interpretable-deep-learning-to-analyse-single-cell-data/?feed_id=32884
#ScienceJobs #Bioinformatics,#SingleCellSequencing,#DeepLearning
Strasbourg, #France #Bioinformatician #PostdoctoralFellow
https://jobrxiv.org/job/igbmc-27778-postdoc-interpretable-deep-learning-to-analyse-single-cell-data/?feed_id=32884

Postdoc: interpretable deep learning to analyse single-cell data

We're keeping research funds for research. Find thousands of job offers like this one at jobRxiv!

jobRxiv
viennese_fingerNov 2, 2022
#introduction time. So I look after the lab operations at Edinburgh Genomics- we have #AllTheToys. #PacBio #illumina #nanopore and all the #skills. Interested in magical things like native #RNAsequencing #SingleCellSequencing RNA/DNA modifications. Also #guitars #Scotland #wildlife. (Is this a dating profile?)