MECOM‑rearranged AML is one of the hardest leukemias to treat — but new combination therapies are changing the outlook.
BET, PI3K/mTOR, and IAP inhibitors are showing strong synergy in preclinical models, reducing leukemia burden and improving survival.
👉 Check full post on ➡️ Banish Cancer Blog.
#AML #LeukemiaResearch #CancerBreakthroughs #TargetedTherapies #MedicalScience #BanishCancer
'Single-cell sequencing reveals the expansion and diversity of T cell subsets in the bone marrow microenvironment of chronic myeloid leukemia' - a Genes & Diseases article on #ScienceOpen:
🔎 https://www.scienceopen.com/document?vid=a1a783a1-5180-487b-b736-d5d814a5fb75
#CancerImmunology #LeukemiaResearch #TCells #SingleCellSequencing
<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d9200406e246">The immune microenvironment plays an important role in leukemia treatment. However, a specific single-cell profiling of the immune alteration in bone marrow of chronic myeloid leukemia (CML) patients is still lacking. We performed multi-level single-cell sequencing to systematically decipher the bone marrow T cell atlas of CML patients. The results exhibited extensive changes of T cells, including the decreased CD4 T cells and increased CD8 T cells in the CML bone marrow. Subpopulation analysis revealed a significant increase of CD8 terminal effector (TE) cells and a significant decrease of CD4 naïve T cells. T cell receptor sequencing showed that the overall diversity of the T cell receptor repertoire was reduced in CML, with the exception of the CD8 TE cell. In addition, CD8 TE cells were the main source of gene expression differences in CD8 T cells. Intercellular communication analysis revealed the altered interaction between CD8 TE and other non-T cells in CML, including neutrophil subtype, indicating the potential regulation of bone marrow microenvironment cells on CD8 TE dynamics. Collectively, our work characterises the alteration of T cell subsets in CML patients at multiple single-cell levels, providing a valuable resource for understanding the immune microenvironment and developing new immune strategies for CML therapy. </p>
Scientists reprogram leukemia cells to combat AML—discover the groundbreaking therapy offering new hope. #LeukemiaResearch #CancerTherapy #AMLBreakthrough
https://geekoo.news/reprogramming-leukemia-a-new-frontier-in-aml-treatment/
A key protein has a hidden role fueling leukemia. Scientists say this discovery could lead to smarter, more effective treatments. #LeukemiaResearch #CancerBreakthrough #TargetedTherapies
https://geekoo.news/hidden-role-of-key-protein-could-transform-leukemia-treatment/
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