GeekooNew gene therapy tools target vision loss at advanced stages—offering hope where none existed before. #visionrestoration #genetherapy #retinaldegeneration
Bo MorganA cure for RP (Retinitus Pigmentosa) has been shown to work with mice in the lab. Clinical trials on humans is scheduled for 2028.
#rp #retinituspigmentosa #blind #retina #retinaldegeneration #lowvision
Came across a 2016 book chapter on retinal neural plasticity, and it discusses specifically RP (Retinitus Pigmentosa) one of many "insults" to the retina that lead to this form of plasticity.
The loss of cones causes a cascade of rewiring resulting in the final stage in a complete change in retinal topology, which loses all typical layers.
It sounds like just having the cone inputs is enough to keep layers organized. The question is whether new inputs would enable functional rewiring...
https://www.ncbi.nlm.nih.gov/books/NBK482309/
What an amazing on-line resource!
#neuroscience #retinaldegeneration #plasticity #retinituspigmentosa #amd #retinaldisease #rp
Retinal Degeneration, Remodeling and Plasticity
Retinal degeneration and remodeling encompasses a group of pathologies at the molecular, cellular and tissue levels that are initiated by inherited retinal diseases like retinitis pigmentosa (RP), genetic and environmental diseases like age-related macular degeneration (AMD) and other insults to the eye/retina including trauma and retinal detachment. These retinal changes and apparent plasticity result in neuronal rewiring and reprogramming events that include alterations in gene expression, de novo neuritogenesis as well as formation of novel synapses, creating corruptive circuitry in bipolar cells through alterations in the dendritic tree and supernumerary axonal growth. In addition, neuronal migration occurs throughout the vertical axis of the retina along Müller cell columns showing altered metabolic signals, and retinal pigment epithelium (RPE) invades the retina forming the pigmented bone spicules that have been classic clinical observations of RP diseases.
AnthonyThis is a long shot, but I wonder whether anyone who sees this knows of good resources for people with one of the macular dystrophies (Stargardt disease, OMD, other). I am looking for information on macular dystrophy specifically, not macular degeneration, which is different (please do not send me macular degeneration resources). I'd appreciate signal boosts--thank you!
#macular #dystrophy #stargardt #retinaldegeneration
#macular #dystrophy #stargardt #retinaldegeneration
PLOS BiologyCiliated #photoreceptor cells have been well studied re #RetinalDegeneration, but what about #PrimaryCilia in other ocular cell types? Study shows that #PrimaryCilium in RPE is essential for development & function; loss results in degeneration #PLOSBiology https://plos.io/3t2PwaG
Deletion of IFT20 exclusively in the RPE ablates primary cilia and leads to retinal degeneration
Most research on retinal degeneration has focused on the ciliated photoreceptor cells, but the role of primary cilia in other ocular cell types has largely been ignored. This study shows that the primary cilium in the retinal pigment epithelium is essential for development and for the proper functioning of this tissue; its absence results in retinal degeneration.
Phys.orgReferenced link: https://medicalxpress.com/news/2023-03-early-cones-retinal-degeneration-thought.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-03-early-cones-retinal-degeneration-thought.html
Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1640626427232911360#m
RT by @physorg_com: Early study shows cones in #retinaldegeneration, thought to be dormant, may retain visual function @currentbiology https://linkinghub.elsevier.com/retrieve/pii/S0960982223002956 https://medicalxpress.com/news/2023-03-early-cones-retinal-degeneration-thought.html
Early study shows cones in retinal degeneration, thought to be dormant, may retain visual function
New UCLA research in mice suggests that "dormant" cone photoreceptors in the degenerating retina are not dormant at all, but continue to function, producing responses to light and driving retinal activity for vision.
TaliY'all, please take your eye health seriously and get checked out ASAP if you notice anything weird vision-wise. Since getting LASIK I had fallen out of getting routine eye exams... lesson learned today when they found multiple holes/tears in my retinas and a detachment in one of them. 👀👀👀