Nexus Eye CareAug 23, 2024

Learn About Retinal Diseases and Macular Degeneration at Nexus Eye Care

Macular degeneration is a leading cause of vision loss, especially in older adults. At Nexus Eye Care, we provide comprehensive information and care for retinal diseases, including macular degeneration. Discover more about the symptoms, causes, and treatment options to protect your vision and maintain eye health.

https://nexuseyecare.com.au/retinal-disease-macular-degeneration/

#MacularDegeneration #RetinalDisease #EyeHealth #VisionCare #NexusEyeCare #EyeCare

Advanced Care for Macular Degeneration at Nexus Eye Care Clinic

Learn about retinal disease and macular degeneration. Find expert care and treatment options at Nexus Eye Care.

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Bo MorganJun 6, 2024

Came across a 2016 book chapter on retinal neural plasticity, and it discusses specifically RP (Retinitus Pigmentosa) one of many "insults" to the retina that lead to this form of plasticity.

The loss of cones causes a cascade of rewiring resulting in the final stage in a complete change in retinal topology, which loses all typical layers.

It sounds like just having the cone inputs is enough to keep layers organized. The question is whether new inputs would enable functional rewiring...

https://www.ncbi.nlm.nih.gov/books/NBK482309/

What an amazing on-line resource!

#neuroscience #retinaldegeneration #plasticity #retinituspigmentosa #amd #retinaldisease #rp

Retinal Degeneration, Remodeling and Plasticity

Retinal degeneration and remodeling encompasses a group of pathologies at the molecular, cellular and tissue levels that are initiated by inherited retinal diseases like retinitis pigmentosa (RP), genetic and environmental diseases like age-related macular degeneration (AMD) and other insults to the eye/retina including trauma and retinal detachment. These retinal changes and apparent plasticity result in neuronal rewiring and reprogramming events that include alterations in gene expression, de novo neuritogenesis as well as formation of novel synapses, creating corruptive circuitry in bipolar cells through alterations in the dendritic tree and supernumerary axonal growth. In addition, neuronal migration occurs throughout the vertical axis of the retina along Müller cell columns showing altered metabolic signals, and retinal pigment epithelium (RPE) invades the retina forming the pigmented bone spicules that have been classic clinical observations of RP diseases.

NCBI Bookshelf