PLOS BiologySep 3, 2025
The #PrimaryCilium regulates several signaling pathways, but what role do these pathways play in #cilium formation? This study shows that modulating Wnt & mTOR signaling affects #ciliogenesis in human retinal epithelial cells @PLOSBiology https://plos.io/45Yg5gB
PLOS BiologyJul 31, 2025
The #PrimaryCilium dynamically assembles & disassembles, but how is this controlled? @cytolabkoc shows that #ciliopathy linked protein Ccdc66 regulates both #cilium stability & length in epithelial cells via microtubules, actin & vesicular trafficking @PLOSBiology https://plos.io/4mdTS4A
PLOS BiologyDec 5, 2023
Ciliated #photoreceptor cells have been well studied re #RetinalDegeneration, but what about #PrimaryCilia in other ocular cell types? Study shows that #PrimaryCilium in RPE is essential for development & function; loss results in degeneration #PLOSBiology https://plos.io/3t2PwaG
Deletion of IFT20 exclusively in the RPE ablates primary cilia and leads to retinal degeneration

Most research on retinal degeneration has focused on the ciliated photoreceptor cells, but the role of primary cilia in other ocular cell types has largely been ignored. This study shows that the primary cilium in the retinal pigment epithelium is essential for development and for the proper functioning of this tissue; its absence results in retinal degeneration.