Placebos
My hypochondriaâs so bad my doctor prescribes me broad spectrum placebos.
Immer mehr Kinder und Jugendliche leben mit #Adipositas. Ein Grazer Forschungsteam erforscht nun einen neuen Ansatz, mit dem Kinder ihren Appetit besser regulieren können. Sie arbeiten mit offenen #Placebos als Intervention fĂŒr Kinder mit Ăbergewicht. #scilog
https://scilog.fwf.ac.at/magazin/kann-der-placeboeffekt-kindern-beim-abnehmen-helfen
Der Placeboeffekt funktioniert auch dann, wenn transparent ist, dass ein Mittel keinen Wirkstoff enthĂ€lt. Ein Grazer Forschungsteam untersucht diesen Ansatz nun als Intervention fĂŒr Kinder mit Ăbergewicht. Erste Studien zeigen, dass offene Placebos den Appetit zĂŒgeln können â doch die Idee polarisiert.
Objective To investigate the efficacy and safety of open-label placebos (OLP) in premenstrual syndrome (PMS). Design Randomised controlled trial. Setting Switzerland, 2018â2020. Participants 150âwomen (18â45 years of age) with PMS or premenstrual dysphoric disorder. Intervention Random assignment (1:1:1) to treatment as usual (TAU), OLP without treatment rationale (OLPâ), or OLP with treatment rationale (OLP+). OLP consisted of two placebo pills per day for 6âweeks. Main outcome measures Primary outcomes were PMS symptom intensity and interference between groups across three menstrual cycles (MC1âMC3); adverse events (ie, safety) were measured at weeks 3 and 6 after the start of the intervention. Secondary outcomes were psychological and somatic subscales of PMS symptom intensity, and adherence. Results From 2 August 2018 to 3 December 2020, 150âwomen were randomly allocated to TAU (n=50), OLPâ (n=50), and OLP+ (n=50), of whom 145 (96.7%) completed trial participation. Groups differed in symptom intensity (F(4)=4.419, p=0.002, r2=0.16) and interference (F(4)=3.159, p=0.014, r2=0.13) across three MCs. Mean symptom intensity at MC3 was lower for OLP+ compared to TAU (b=â9.97, SE=2.85, t(412)=3.50, p<0.001, d=0.90) and to OLPâ (b=â6.10, SE=2.89, t(411)=2.11, p=0.036, d=0.55), but OLPâ and TAU did not differ (b=â3.87, SE=2.87, t(411)=1.35, p=0.177, d=0.35). Mean interference at MC3 was lower for OLP+ compared to TAU (b=â1.23, SE=0.54, t(443)=2.30, p=0.022, d=0.55) and to OLPâ (b=â1.10, SE=0.54, t(442)=2.02, p=0.044, d=0.48), but OLPâ and TAU did not differ (b=â0.14, SE=0.54, t(442)=0.26, p=0.799, d=0.06). Four non-serious adverse events were reported in OLPâ (n=1) and OLP+ (n=3). Improvement in psychological and somatic symptom intensity was comparable to primary outcomes. Adherence to the OLP intervention was high (93.18±18.95%), with no difference between groups. Conclusions The results of our clinical trial indicate that OLP provided with a treatment rationale is an effective, safe, and acceptable treatment for PMS. Trial registration ClinicalTrials.gov [NCT03547661][1] (submitted 2 May 2018). Data are available in a public, open access repository. Meta-data is openly accessible on the data repository Harvard Dataverse. Upon reasonable request, relevant anonymised participant-level data will be made available. [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT03547661&atom=%2Febmed%2Fearly%2F2025%2F03%2F05%2Fbmjebm-2024-112875.atom
All Placebos are not created equal
https://www.samstack.io/p/all-placebos-are-not-created-equal
#HackerNews #All #Placebos #are #not #created #equal #placebos #health #science #psychology #research
Have you ever heard of a Perkins Tractor? If you lived in London in the 18th Century, you could buy a pair of Perkins Tractors (shown above) for the steep price of five guineas, and wave them over an aching part of your body for about twenty minutes as a way of relieving your pain. They worked, sort of. People who bought and used Perkins Tractors
Warum redet keiner ĂŒber #Placebos?!
â#Homöopathie wirkt nicht ĂŒber den #Placebo_Effekt hinaus.â
Was bedeutet das eigentlich? Das haben wir mit der Hilfe zweier Experten recherchiert und es stellt sich heraus: es gibt tatsÀchlich etwas, das die #Medizin von der Homöopathie lernen kann.
https://www.yewtu.be/watch?v=tpVVCQrOdJw
EricGeneric
Julia Clement
A Joke A Day
Lauhaz NasjÄ
Wissenschaftsfonds FWF
Dr Susi Arnott
Hacker News
ConscienHealth
Norbert_R đ
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