Heavinly Tweed @ Wharf Chambers - 03 Apr feat. NMDA

#SESH #NMDA

https://sesh.sx/e/1967286

The article discusses a study that uses non-invasive brain scanning combined with computer modeling to measure how the Alzheimer’s drug memantine interacts with brain receptors in living patients, aiming to confirm drug action without invasive procedures. It also shows how these methods can track changes in brain activity over time in people with cognitive impairment or Alzheimer’s disease.

This approach is of interest to psychology readers because it demonstrates how brain activity and receptor dynamics relate to cognitive function and disease progression, and it highlights innovative methods for studying brain mechanisms in living humans.

Article Title: New brain scanning method safely tracks how Alzheimer’s drugs work in living patients

Link to PsyPost Article: https://www.psypost dot org/new-brain-scanning-method-safely-tracks-how-alzheimers-drugs-work-in-living-patients/

Copy and paste broken link above into your browser and replace "dot" with "." for link to work. We have to do it this way to avoid displaying copyrighted images.

#neuroimaging #alzheimersdisease #memantine #nmda-receptors #magnetoencephalography

Researchers at Oregon Health & Science University successfully mapped the precise binding sites where disease-associated #autoantibodies attach to the #NMDA receptor, identifying a novel #therapeutic target for anti-NMDA receptor encephalitis.
#Neuroscience #MolecularNeuroscience #MolecularBiology #sflorg
https://www.sflorg.com/2026/01/ns01142601.html
Scientists identify target to treat devastating brain disease

This discovery opens the door to the first targeted drug therapies for anti-NMDA receptor encephalitis

Naked Mole Rats, Aspartame, Restless Leg Syndrome | Robert Sapolsky Father-Offspring Interviews #91

YouTube
🌘 NMDA 受體拮抗劑:比您想知道的更多
➤ 解密 NMDA 受體的亞基選擇性、結合動態與神經元靶向如何影響藥物效用
https://grillbert.substack.com/p/nmda-receptor-antagonists-a-bit-more
這篇文章深入探討了 NMDA 受體拮抗劑的作用機制,解釋了它們為何能產生麻醉、治療阿茲海默症或憂鬱症等效果。作者透過比較美金明 (Memantine) 和氯胺酮 (Ketamine) 的例子,說明瞭藥物對 NMDA 受體不同亞基的選擇性、其與受體結合後被「囚禁」或「閃爍」的動態,以及藥物作用於興奮性或抑制性神經元的差異,共同決定了其複雜的生理和行為影響。
+ 氯胺酮和美金明竟然作用機制差異這麼大,以前都只知道它們是NMDA拮抗劑,這篇分析真的讓我大開眼解!
+ 作者的文筆很生動,把複雜的 NMDA 受體機制講得很有趣,特別是「囚禁」和「閃爍」的比喻。
#神經科學 #藥理學 #NMDA 受體
NMDA Receptor Antagonists: Slightly More than you Wanted to Know

Insights from Memantine and Ketamine's divergent effects on the Brain

Biomusings

Insight Article: A new mode of action for unconventional NMDA receptors

Presynaptic #NMDA receptors can shape timing-dependent long-term depression in a way that departs from their classic postsynaptic role. #Neuroscience
https://elifesciences.org/articles/107049?utm_source=mastodon&utm_medium=social&utm_campaign=organic_insights

Memantine‐induced functional rewiring of the glutamate synapse in the striatum of dopamine transporter knockout rats - Caffino - British Journal of Pharmacology
#openaccess
#NMDA
#ionchannels

https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17403?af=R

https://ncbi.nlm.nih.gov/pmc/articles/PMC10479373/ Synaptic Plasticity 101: The Story of the AMPA Receptor for the Brain Stimulation Practitioner (Brown, et al, 2022) #brains #Neuroplasticity #ampa #nmda #ketamine #mentalhealth #NeuroScience
Synaptic Plasticity 101: The Story of the AMPA Receptor for the Brain Stimulation Practitioner

The fields of Neurobiology and Neuromodulation have never been closer. Consequently, the phrase “synaptic plasticity” has become very familiar to non-basic scientists, without actually being very familiar. We present the “Story ...

PubMed Central (PMC)

https://deborahcopaken.substack.com/p/could-ketamine-cure-tinnitus
#tinnitus #ketamine #KetamineInfusion #clinicaltrial #nmda

I don't know for sure what really caused my tinnitus to become continuous. But the onset is strongly correlated with my two consecutive surgical awarenesses. Got pretty noticeable with the first one and now it's non-stop, loud, high pitched, and completely maddening.

I can't afford #ketamineinfusions out of pocket, regardless of whether it's for my #PTSD or for tinnitus.
#ottawa #ontario

Could Ketamine Cure Tinnitus?

I entered a clinical trial to see if ketamine would stop the constant ringing in my left ear. The catch? I'd have to spend 90 minutes, while tripping, completely immobile in an MRI.

Ladyparts