Il y a des projets auxquels j'ai participé et / ou donné mon avis professionnel qui ne décollent pas, et dont la dénomination se diffuse dans le "domaine public" : les clients potentiels ont des attentes non-dites...
#BioInformatique #InVivo #InVitro #InSilico #JumeauNumérique
Efforts to reduce animal experiments are important and should be pursued. But despite progress in #AI, #organoids, and #InSilico models, I’m not convinced we’re there yet — especially in #neuroscience, where #complexity and systemic #context matter. However, I do think we should stay committed and aim for reduction by all available means. I recently came across this article, which gives a good overview of the current state of the field:
#Insilico #Medicine crea el primer medicamento real mediante inteligencia artificial cuya capacidad para #curar una enfermedad pulmonar mortal en humanos ya ha sido probada.
El fundador de la empresa afirma que la #IA podrá indicar a los investigadores nuevos tratamientos en los que nunca habrían pensado por sí solos y acelerar las fases iniciales del #descubrimiento de nuevos tratamientos, ofreciendo sugerencias sobre qué objetivos deben alcanzarse con los #fármacos.
Water as one of the main sources of life, holds an important aspect to public health and safety. Up until now there have been many concerns about water pollution especially in developing countries. Heavy polluted water that is not treated well could cause many concerning diseases that can lead to deaths. Contaminants that came from chemical, physical, and biological compounds are commonly found in the water sources. Gram negative bacteria (GNB) has been shown to develop multiple drugs and antibiotics resistant, making the infection more fatal. This has become a major concern on public health especially in water treatment as it becomes more challenging. Our study investigates human coagulation factor II that is responsible for blood clotting as a possible method for water treatment against GNB. By investigating the coagulation protein interaction with several bacterial lipopolysaccharides proteins and calculating the binding affinity of the interaction, the results show factor II has a lower binding affinity compared to previously studied factor VII. This shows possibilities of factor II to hydrolyse several gram-negative bacteria to act as a potential treatment against these GNBs.
gaby_wald
Fabrizio Musacchio
José A. Callejón
Quantum Observer
JamesLundblad
Marlene Mengoni
Arli A P