ISOGGDec 1, 2025
“Our finding multiple high‐level and sub‐haplogroup contexts of causal mtDNA pathogenic variants in PMD patients proves that although a possible contributor, the modifying effects of haplogroup context are not a main driver of the diagnostic disparities evident for African patients.” #DNA #Haplogroup #HaplogroupL #isogg #mitochrondria #PMD #mtDNA https://pmc.ncbi.nlm.nih.gov/articles/PMC12254466/
Mitochondrial DNA Pathogenic Variant Prevalence in Primary Mitochondrial Disease Patients With African (L) Mitochondrial Genome Haplogroups

Primary mitochondrial diseases (PMD) are caused by pathogenic variants in over 350 genes, 37 of which are located in mitochondrial DNA (mtDNA). While more than 100 mtDNA variants have confirmed disease associations, there are few reports of ...

PubMed Central (PMC)
ISOGGDec 12, 2024

“The mtDNA haplogroup D and white matter microstructure regulated the cognitive function among community-dwelling older adults.” #isogg #DNA #epigenetics #haplogroup #mtDNA #mitochondria #geneadons

https://www.sciencedirect.com/science/article/abs/pii/S0167494323002753

ISOGGNov 14, 2024

These findings suggest that elevated FI score of mtDNA variants might contribute to premature aging in young adulthood. (Preprint) #isogg #dna #mitochondrial #mtDNA #haplogroup #aging #geneadons #epigenetics #geneticgenealogy

https://www.researchsquare.com/article/rs-4340944/v1

Mitochondrial DNA variants and their impact on epigenetic and biological aging in young adulthood

The pace of biological aging varies between people independently of chronological age and mitochondria dysfunction is a key hallmark of biological aging. We hypothesized that higher functional impact (FI) score of mitochondrial DNA (mtDNA) variants might contribute to premature aging and teste...

Mark DarbyshireJun 8, 2024

A distant Derby cousin and I recently got our Big Y-700 results back. I'm hoping other cousins from the last few centuries to millennium will test too to refine the results, but for now – behold our haplogroup! https://discover.familytreedna.com/y-dna/I-FTF58625

#Genealogy #Ancestry #FamilyHistory #Genetics #DNA #YDNA #Haplogroup #FamilyTreeDNA

Welcome to FamilyTreeDNA Discover

Discover more about your paternal ancestry and join in on the research!

FamilyTreeDNA Discover
ℵ₀ 🏳️‍⚧️🏴‍☠️Jan 20, 2024

https://www.nature.com/articles/s41579-022-00846-2

Long COVID: major findings, mechanisms and recommendations

https://www.sciencedirect.com/science/article/pii/S2589004223011719

Impact of peripheral mitochondrial DNA level on immune response after COVID-19 vaccination

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474411/
Common mitochondrial haplogroups as modifiers of the onset-age for critical COVID-19

#COVID19 #LongCovid #mitochondria #mtDNA #Haplogroup #InnateImmuneMemory #InnateImmunity

Long COVID: major findings, mechanisms and recommendations | Nature Reviews Microbiology

Long COVID is an often debilitating illness that occurs in at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. More than 200 symptoms have been identified with impacts on multiple organ systems. At least 65 million individuals worldwide are estimated to have long COVID, with cases increasing daily. Biomedical research has made substantial progress in identifying various pathophysiological changes and risk factors and in characterizing the illness; further, similarities with other viral-onset illnesses such as myalgic encephalomyelitis/chronic fatigue syndrome and postural orthostatic tachycardia syndrome have laid the groundwork for research in the field. In this Review, we explore the current literature and highlight key findings, the overlap with other conditions, the variable onset of symptoms, long COVID in children and the impact of vaccinations. Although these key findings are critical to understanding long COVID, current diagnostic and treatment options are insufficient, and clinical trials must be prioritized that address leading hypotheses. Additionally, to strengthen long COVID research, future studies must account for biases and SARS-CoV-2 testing issues, build on viral-onset research, be inclusive of marginalized populations and meaningfully engage patients throughout the research process. Long COVID is an often debilitating illness of severe symptoms that can develop during or following COVID-19. In this Review, Davis, McCorkell, Vogel and Topol explore our knowledge of long COVID and highlight key findings, including potential mechanisms, the overlap with other conditions and potential treatments. They also discuss challenges and recommendations for long COVID research and care.

Bibliolater 📚 📜 🖋Jan 5, 2024

"The first such migration is predicted to have occurred at the onset of the Neolithic, and accordingly J1e parallels the establishment of rain-fed agriculture and semi-nomadic herders throughout the Fertile Crescent. Subsequently, J1e lineages might have been involved in episodes of the expansion of pastoralists into arid habitats coinciding with the spread of Arabic and other Semitic-speaking populations."

Chiaroni, J., King, R., Myres, N. et al. The emergence of Y-chromosome haplogroup J1e among Arabic-speaking populations. Eur J Hum Genet 18, 348–353 (2010). https://doi.org/10.1038/ejhg.2009.166 #Journal #Article #Science #STEM #Genetics #Anthropology #Genealogy #Biology #Haplogroup #Neolithic #Arabic #Languages #Pastoralism #Academia #Academic #Academics @science @biology @anthropology

KennethOct 29, 2023

Hypothesis: Racist groups have never, to the best of my knowledge, used the #R1b #haplogroup as a pseudo-scientific criterion of whiteness because it's not white enough.

#racism
#ethnicity
#genomics

Bibliolater 📚 📜 🖋Jul 25, 2023
Nicolas Broccard, Nuno Miguel Silva, Mathias Currat. "Simulated patterns of mitochondrial diversity are consistent with partial population turnover in Bronze Age Central Europe." American Journal of Biological Anthropology 177.1 (2021) 134-146 https://doi.org/10.1002/ajpa.24431 #OpenAccess #OA #Research #Article #Ancient #ancientDNA #DNA #Genetics #Haplogroup #Plague #Yamnaya #Biology #Anthropology #Science #Europe #BronzeAge #Demography #Academia #Academic #Academics @anthropology @science
Show threadKennethApr 19, 2023

@igd_news

Has anyone checked his #haplogroup

#dallas #texas #thisweekinfascism

Show threadanatoleFeb 21, 2023

Definitions 🧵:
A #haplogroup is a combination of #alleles that tend to be inherited together.
An #allele is a variation of the same sequence of nucleotides at the same place on a DNA molecule.

#Haplogroups pertain to a single line of descent. As such, individual membership of a haplogroup relies on a small proportion of the #genetic material possessed by that individual.

Mothers pass on mitochondrial #DNA unmixed to all their children; so the #ancestry can be traced along the maternal line.