How does nutrient deficiency in the #tumor #microenvironment lead to metabolic reprogramming? This study reveals a mechanism for glioblastoma survival via switching from #glycolysis to #FattyAcid oxidation in mice, with implications for cancer medicine @PLOSBiology https://plos.io/3P6pSg4
USP7 facilitates brain tumor survival upon glucose deprivation by regulating phosphofructokinase muscle-type nuclear translocation in mice

We discover a novel function of PFKM in promoting glioma cell survival under glucose deficiency by switching metabolism from glycolysis to FAO. Upon GD, the levels of F-2,6-BP are decreased, leading to the enhanced interaction between USP7 and PFKM. USP7 then deubiquitinates PFKM K615 and promotes its nuclear translocation. Nuclear PFKM enhances c-Myc-dependent expression of CPT1B and the activity of FAO, and promotes tumor cell survival under GD.

Development of drug targets

Jens Hjörleifsson talk

Amf n amfr
#MoonlightFunction
#glycolysis #amf #amfr

https://www.genecards.org/cgi-bin/carddisp.pl?gene=AMFR

‬‬Hexokinase 2 (HK2) is known for its metabolic role in #glycolysis. This study shows that it also functions as an #RNAbindingProtein that regulates mRNA translation, particularly of SOX10, promoting #melanoma cell proliferation independently of glycolysis @PLOSBiology https://plos.io/3ViI1qL
Upregulating #mitochondrial Ca2+ uniporter (MCU) helps #ColorectalCancer cell growth, but what about its regulators? Study shows that MICU2 ensures metabolic flexibility between #glycolysis & #OxPhos and regulates #cancer cell proliferation #PLOSBiology https://plos.io/40pW69s
MICU2 up-regulation enhances tumor aggressiveness and metabolic reprogramming during colorectal cancer development

Upregulation of the mitochondrial calcium uniporter (MCU) has been shown to facilitate colorectal cancer cell growth, but the contributions of MCU-regulatory proteins are not known. These authors show that MICU2 ensures metabolic flexibility between anaerobic glycolysis and oxidative phosphorylation and regulates cancer cell proliferation.

Exploring the mechanisms of glycolytic genes involvement in pulmonary arterial hypertension through integrative bioinformatics analysis. https://doi.org/10.1111/jcmm.18447 #Bioinformatics #Degs #Glycolysis #MachineLearning #Pah
The K+ channel KCNK1 is differentially expressed in many #tumors, but why? Study shows that KCNK1 overexpression in #BreastCancer promotes proliferation, invasion & #metastasis by increasing #glycolysis & activating #LactateDehydrogenase. #PLOSBiology https://plos.io/3VTNdCr
KCNK1 promotes proliferation and metastasis of breast cancer cells by activating lactate dehydrogenase A (LDHA) and up-regulating H3K18 lactylation

KCNK1 is a potassium channel differentially expressed in many tumors, but the mechanisms underlying its function in breast cancer remain unclear. This study shows that KCNK1 is overexpressed in breast cancer promoting proliferation, invasion and metastasis by increasing glycolysis and activating Lactate Dehydrogenase A.

Unlocking the secrets of citrus greening: Cultivating Candidatus Liberibacter asiaticus

Huanglongbing (HLB), also known as citrus greening, poses a severe threat to citrus production worldwide. The disease is caused by the bacterium Candidatus Liberibacter asiaticus (Las), which has been challenging to culture outside its host due to its intracellular nature and genome reduction.

Phys.org

The Tricarboxylic Acid Cycle

#AcetylCoA, #CitricAcidCycle, #Glycolysis, #KrebsCycle, #TCACycle #Biochemistry There are several metabolic pathways have been identified, those are used to liberate energy from food components. In the glycolytic…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs | Read More -

https://micrordt.wordpress.com/2024/04/27/the-tricarboxylic-acid-cycle/

The Tricarboxylic Acid Cycle

#AcetylCoA, #CitricAcidCycle, #Glycolysis, #KrebsCycle, #TCACycle #Biochemistry There are several metabolic pathways have been identified, those are used to liberate energy from food components. In…

Medical Microbiology & RDT Labs

Glycolysis: The Breakdown Of Glucose To Pyruvate

#GlucoseBreakdown, #Glycolysis #Biochemistry There are several metabolic pathways have been identified in microorganisms, to catabolize glucose and other sugars. Because of this metabolic…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs | Read More -

https://micrordt.wordpress.com/2024/04/27/glycolysis-the-breakdown-of-glucose-to-pyruvate/

Glycolysis: The Breakdown Of Glucose To Pyruvate

#GlucoseBreakdown, #Glycolysis #Biochemistry There are several metabolic pathways have been identified in microorganisms, to catabolize glucose and other sugars. Because of this metabolic…. Medical…

Medical Microbiology & RDT Labs

Wow! This is amazing. Imagine getting a visual of the bio-mechanical processes in our cell. How enzymes and molecules interact with each other. Gosh this is awesome to look at.
The channel WEHImovies that produces all these superb videos for education is: invidious.private.coffee/chann… there is lots of cool films showing (and explaining/narrating) the inside of the cell and all the weird things and processes that goes on on the quantum level. Magnified x10,000,000 times gives a unique look.

I want to take a deeper look at the visualization of the energy production process in our organelle the mitochondria, step by step. This is the Cellular Respiration and metabolism process of how we make energy.

1) Glycolysis
The Glycolysis pathway process. This is the anaerobic pathway (no oxygen involved) where glucose sugar get broken down into two units of pyruvate: invidious.private.coffee/watch…

2) Pyruvate Oxidation (also called Pyruvate decarboxylation)
This is an aerobic process. Here the pyruvate get converted to Acetyl-CoA by the enzyme complex pyruvate dehydrogenase complex: invidious.private.coffee/watch…

3) Citric Acid Cycle (also called Krebs cycle (after Hans Adolf Krebs who identified the process) or Tricarboxylic Acid cycle)
An eight step process and central driver of cellular respiration. Here the Acetyl-CoA, fatty acids and amino acids enter the cycle and goes through a series of chemical reactions that create 2 units of ATP (Adenosine Triphosphorate), CO2, NADH and FADH2 (both are coenzymes). Carbon dioxide is produced as a byproduct which we need to expel through breathing (the main reason why we breath, to expel CO2, we usually have ample of oxygen in us): invidious.private.coffee/watch…

4) Electron Transport Chain
During the electron transport chain high-energy electrons are transferred from molecules such as NADH and FADH2 to oxygen, with the energy released being used to pump protons across the inner mitochondrial membrane. This creates a proton gradient, which drives the synthesis of 34-38 units of ATP by the enzyme ATP synthase. Fun fact, that little nano motor unit (ATP Synthase) spins around at about 7800rpm: invidious.private.coffee/watch…

5) Oxidative Phosphorylation
During oxidative phosphorylation, ATP is produced as a result of the transfer of electrons through the electron transport chain. One key difference between oxidative phosphorylation and the electron transport chain is that oxidative phosphorylation specifically refers to the production of ATP through the coupling of electron transport and ATP synthesis. This process involves the combination of electrons, protons and oxygen molecule that produce water as a byproduct.
Synthesis of ATP: invidious.private.coffee/watch…

#Molecular #Animation #Biology #Cell #Mitochondria #Energy #Science #Education #ATP #OxidativePhosphorylation #CitricAcidCycle #Glycolysis #ElectronTransportChain #PyruvateOxidation

WEHImovies

Biomedical animations, news and videos of research from WEHI (The Walter and Eliza Hall Institute of Medical Research)

Invidious