mymedschoolJun 5

Summary of metabolic pathways biochemistry
#NEETPG2026 #INICET #NEXTExam #HighYieldReview #Biochemistry #Metabolism #Glycolysis #TCACycle #UreaCycle #HMPShunt #Gluconeogenesis #InbornErrors #Vitamins #EnzymeRegulation #Thiamine #VitaminB12 #InbornErrorsOfMetabolism #G6PD #VonGierke #Galactosemia

https://mymedschool.org/portfolio/summary-of-metabolic-pathways-high-yield-chart-for-neet-pg-usmle/?utm_source=mastodon&utm_medium=jetpack_social

Summary of Metabolic Pathways: High-Yield Chart for NEET PG & USMLE

Can you instantly pinpoint where glycolysis, the TCA cycle, and the urea cycle cross paths? Master the regulatory intersections, rate-limiting steps, and critical vitamin cofactors with our integrated biochemical roadmap on mymedschool.org.

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pub2postMay 25

Metabolic Roadmap for Stem Cell Fate

🧩 Stem cells utilize intrinsic and extrinsic metabolic cues.

#StemCells #Glycolysis #Metabolism #TCA #Research https://tnyp.me/0agcfUp9/m

mymedschoolApr 8

🔄 The Master Toggle: Mastering Fructose-2,6-bisphosphate! 🔄
#USMLEStep1 #MedEd #Biochemistry #Metabolism #Glycolysis #Gluconeogenesis #PFK2 #Insulin #Glucagon #Step1Prep #HighYield #MedSchool #Endocrinology #Physiology #FutureDoctor #StudyGram #MedTwitter

https://mymedschool.org/portfolio/u01-01-097-regulation-by-fructose-26-bisphosphate/?utm_source=mastodon&utm_medium=jetpack_social

U01.01.097 Fructose-2,6-bisphosphate: The Master Switch of Glycolysis and Gluconeogenesis

Master the pivotal role of Fructose-2,6-bisphosphate (F-2,6-BP) in metabolic regulation with our U01.01.097 guide. Learn how the PFK-2/FBPase-2 bifunctional enzyme complex responds to Insulin and Glucagon to toggle between energy production and glucose synthesis. Essential biochemistry for USMLE Step 1 prep on mymedschool.org.

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mymedschoolApr 8

🚦 The Metabolic Gas Pedal: Mastering Glycolysis Regulation! 🚦
#USMLEStep1 #MedEd #Biochemistry #Metabolism #Glycolysis #PFK1 #Insulin #Glucagon #Step1Prep #HighYield #MedSchool #Endocrinology #Physiology #FutureDoctor #StudyGram #MedTwitter

https://mymedschool.org/portfolio/u01-01-096-glycolysis-regulation/?utm_source=mastodon&utm_medium=jetpack_social

U01.01.096 Glycolysis Regulation: PFK-1, Pyruvate Kinase & Hormonal Control

Master the complex regulation of Glycolysis with our U01.01.096 guide. Explore the three irreversible steps, the pivotal role of PFK-1, and how Fructose-2,6-bisphosphate acts as the master metabolic switch. Understand the hormonal influence of Insulin and Glucagon on enzyme phosphorylation. Essential preparation for USMLE Step 1 on mymedschool.org.

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mymedschoolApr 8

🧪 The First Step of Glycolysis: Hexokinase vs. Glucokinase! 🧪
#USMLEStep1 #MedEd #Biochemistry #Metabolism #Glycolysis #Hexokinase #Glucokinase #Step1Prep #HighYield #MedSchool #Endocrinology #Diabetes #FutureDoctor #StudyGram #MedTwitter

https://mymedschool.org/portfolio/u01-01-095-hexokinase-vs-glucokinase/?utm_source=mastodon&utm_medium=jetpack_social

U01.01.095 Hexokinase vs. Glucokinase: High-Yield Biochemistry Comparison

Master the critical differences between Hexokinase and Glucokinase with our U01.01.095 guide. Explore Km, Vmax, tissue distribution, and hormonal regulation. Understand why Glucokinase acts as a glucose sensor in the liver and pancreas, and how Hexokinase ensures energy supply in peripheral tissues. Essential for USMLE Step 1 preparation on mymedschool.org.

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mymedschoolApr 6

🚦 The Metabolic Traffic Lights: Master the Rate-Limiting Steps! 🚦
#USMLEStep1 #MedEd #Biochemistry #Metabolism #Enzymes #Step1Prep #HighYield #MedSchool #Endocrinology #Glycolysis #LipidMetabolism #Statins #FutureDoctor #StudyGram

https://mymedschool.org/portfolio/u01-01-090-rate-determining-enzymes-of-metabolic-processes/?utm_source=mastodon&utm_medium=jetpack_social

U01.01.090 Metabolic Rate-Limiting Enzymes: Hormonal & Allosteric Regulation Guide

Master the master-regulators of metabolism with our U01.01.090 guide. Learn the rate-limiting steps for Glycolysis (PFK-1), Gluconeogenesis (F-1,6-BPase), Fatty Acid Synthesis (ACC), and the Urea Cycle (CPS I). Understand how Insulin, Glucagon, and energy markers like AMP/ATP shift metabolic flux. Essential USMLE Step 1 biochemistry preparation available on mymedschool.org.

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PLOS BiologyMar 19
How does nutrient deficiency in the #tumor #microenvironment lead to metabolic reprogramming? This study reveals a mechanism for glioblastoma survival via switching from #glycolysis to #FattyAcid oxidation in mice, with implications for cancer medicine @PLOSBiology https://plos.io/3P6pSg4
USP7 facilitates brain tumor survival upon glucose deprivation by regulating phosphofructokinase muscle-type nuclear translocation in mice

We discover a novel function of PFKM in promoting glioma cell survival under glucose deficiency by switching metabolism from glycolysis to FAO. Upon GD, the levels of F-2,6-BP are decreased, leading to the enhanced interaction between USP7 and PFKM. USP7 then deubiquitinates PFKM K615 and promotes its nuclear translocation. Nuclear PFKM enhances c-Myc-dependent expression of CPT1B and the activity of FAO, and promotes tumor cell survival under GD.

CharrveinDec 11, 2025

Development of drug targets

Jens Hjörleifsson talk

Amf n amfr
#MoonlightFunction
#glycolysis #amf #amfr

https://www.genecards.org/cgi-bin/carddisp.pl?gene=AMFR

PLOS BiologySep 17, 2025
‬‬Hexokinase 2 (HK2) is known for its metabolic role in #glycolysis. This study shows that it also functions as an #RNAbindingProtein that regulates mRNA translation, particularly of SOX10, promoting #melanoma cell proliferation independently of glycolysis @PLOSBiology https://plos.io/3ViI1qL
PLOS BiologyOct 29, 2024
Upregulating #mitochondrial Ca2+ uniporter (MCU) helps #ColorectalCancer cell growth, but what about its regulators? Study shows that MICU2 ensures metabolic flexibility between #glycolysis & #OxPhos and regulates #cancer cell proliferation #PLOSBiology https://plos.io/40pW69s
MICU2 up-regulation enhances tumor aggressiveness and metabolic reprogramming during colorectal cancer development

Upregulation of the mitochondrial calcium uniporter (MCU) has been shown to facilitate colorectal cancer cell growth, but the contributions of MCU-regulatory proteins are not known. These authors show that MICU2 ensures metabolic flexibility between anaerobic glycolysis and oxidative phosphorylation and regulates cancer cell proliferation.