PLOS BiologyThe K+ channel KCNK1 is differentially expressed in many #tumors, but why? Study shows that KCNK1 overexpression in #BreastCancer promotes proliferation, invasion & #metastasis by increasing #glycolysis & activating #LactateDehydrogenase. #PLOSBiology https://plos.io/3VTNdCr
KCNK1 promotes proliferation and metastasis of breast cancer cells by activating lactate dehydrogenase A (LDHA) and up-regulating H3K18 lactylation
KCNK1 is a potassium channel differentially expressed in many tumors, but the mechanisms underlying its function in breast cancer remain unclear. This study shows that KCNK1 is overexpressed in breast cancer promoting proliferation, invasion and metastasis by increasing glycolysis and activating Lactate Dehydrogenase A.