PLOS BiologySep 17, 2025
‬‬Hexokinase 2 (HK2) is known for its metabolic role in #glycolysis. This study shows that it also functions as an #RNAbindingProtein that regulates mRNA translation, particularly of SOX10, promoting #melanoma cell proliferation independently of glycolysis @PLOSBiology https://plos.io/3ViI1qL
Gal Haimovich 😷🔬☣🏳️‍🌈🏳️‍⚧Nov 6, 2023

This looks like a very interesting #preprint @biorxivpreprint from Christine Mayr lab:

"The FXR1 network acts as signaling scaffold for actomyosin remodeling"
#RNA #mRNA #RNABindingProtein #microscopy

https://www.biorxiv.org/content/10.1101/2023.11.05.565677v2

PLOS BiologyJul 24, 2023
Microglia-mediated inflammation is involved in #IschemicStroke. This study reveals that the TF NR4A1 has a novel role in #microglia as an #RNAbindingProtein that destabilizes pro-inflammatory transcripts & alleviates ischemic #BrainInjury #PLOSBiology https://plos.io/3Q4w4n8
Noncanonical contribution of microglial transcription factor NR4A1 to post-stroke recovery through TNF mRNA destabilization

Microglia-mediated neuroinflammation is involved in neurological diseases such as ischemic stroke, but the mechanisms that prevent unstrained inflammation are unclear. This study reveals that the canonical transcription factor NR4A1 has a novel role in microglia as an RNA-binding protein that localizes to processing bodies to destabilize pro-inflammatory transcript and alleviate ischemic brain injury.

Gal Haimovich 😷🔬☣🏳️‍🌈🏳️‍⚧Jan 27, 2023

This looks like a super-useful method!

"Oligonucleotide-directed proximity-interactome mapping (O-MAP): A unified method for discovering RNA-interacting proteins, transcripts and genomic loci in situ"

#RNA #mRNA #mRNP #RNABindingProtein

https://www.biorxiv.org/content/10.1101/2023.01.19.524825v1