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#Centromere research yields new insights into the mechanisms of #chromosome #segregation errors.
https://phys.org/news/2024-05-centromere-yields-insights-mechanisms-chromosome.html
Researchers from the Hubrecht Institute's Kops group, in collaboration with researchers from the University of Edinburgh, have made a surprising new discovery in the structure of the centromere, a structure involved in ensuring that chromosomes are segregated properly when a cell divides. Mistakes in chromosome segregation can lead to cell death and cancer development.
Secrets of #cell_division revealed by cutting-edge imaging technique.
#cohesin #microscopy #chromatids
https://phys.org/news/2024-03-secrets-cell-division-revealed-edge.html
A study by Fena Ochs, new Group Leader and Associate Professor at Biotech Research & Innovation Center (BRIC) University of Copenhagen, delves deep into the intricate world of cell division. The study, published in Science, sheds light on the role of cohesin, which is a crucial protein complex that helps to faithfully segregate genetic material during cell division.
#Cohesin can resolve sister #chromatids already in G2 phase independent of #condensin - suggesting DNA #loopextrusion as generic mechanism for segregating #replicated genomes shared across different Structural Maintenance of #Chromosomes (SMC) protein complexes
Paul Batty, Daniel Gerlich et al #viennabiocenter
https://www.embopress.org/doi/10.15252/embj.2023113475
Fitting two metres of DNA into a microscopic cell nucleus: that is the challenge that cohesin takes on, folding long chromosomes into many loops. CTCF, a nuclear protein, binds to DNA and acts as a barrier to cohesin, regulating its activity and restraining loop formation to specific areas of the genome. In a study published in Nature, IMP scientists and collaborators visualise CTCF in real time, showing that its role as a regulator of genome architecture is much more fine-tuned than expected.
Referenced link: https://phys.org/news/2023-03-cohesin-dna-loops-human-genome.html
Discuss on https://discu.eu/q/https://phys.org/news/2023-03-cohesin-dna-loops-human-genome.html
Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/physorg_com/status/1641149993682599944#m
Understanding how #cohesin makes #DNA loops in the human genome and its role in Cornelia de Lange syndrome @CNIO_Cancer @NatureComms https://www.nature.com/articles/s41467-023-36900-7 https://phys.org/news/2023-03-cohesin-dna-loops-human-genome.html
Cohesin is a ring-shaped protein that surrounds and moves around the DNA molecule, forming the loops. It is a crucial process for the cell. Understanding how cohesin works has been one of the challenges of molecular biology in recent decades. A study now published by researcher Ana Losada's group at The Spanish National Cancer Research Centre (CNIO) will serve to deepen our understanding of the disease known as Cornelia de Lange syndrome.
PLOS Biology
Rob Beagrie
CellBioNews
Emma Rusch
The EMBO Journal
IMP
Phys.org