#Cohesin can resolve sister #chromatids already in G2 phase independent of #condensin - suggesting DNA #loopextrusion as generic mechanism for segregating #replicated genomes shared across different Structural Maintenance of #Chromosomes (SMC) protein complexes

Paul Batty, Daniel Gerlich et al #viennabiocenter
https://www.embopress.org/doi/10.15252/embj.2023113475

How does #condensin #SMC complex extrude #DNA loops?

Joaquim Roca and coworkers show that it generates DNA #translocation steps by pinching a short negatively #supercoiled DNA loop during each round of #ATP #hydrolysis
https://www.embopress.org/doi/10.15252/embj.2022111913