Separase plays a key role in cleaving #cohesin complexes that hold #chromosomes together during cell division. Martin Anger explores a @PLOSBiology study showing that #separase activity is controled by #cyclin B/CDK1 & securin in #meiosis (and not SGO2). Paper: https://plos.io/3RAoccz Primer: https://plos.io/43L91UR

How do neural #stemcells transition from developmental to adult states?
Anja Urbach, Juan Manuel Encinas and coworkers show that lifelong neurogenesis in the mouse #hippocampus involves postnatal precursor generation in the dentate gyrus depending on #cyclin D2 expression
https://www.embopress.org/doi/full/10.1038/s44318-023-00011-2

"[...] a tension-dependent signal on the #nucleus that sets the time for nuclear envelope permeabilization (NEP) and mitotic entry. This signal relies on #actomyosin #contractility, which unfolds the nucleus during the G2-M transition, activating the stretch-sensitive #cPLA2 on the nuclear envelope and regulating the nuclear translocation of #cyclin B1.[...]"
https://rupress.org/jcb/article-abstract/221/12/e202205051/213539/Nuclear-tension-controls-mitotic-entry-by
#BioMechanics #MechanoBiology #NuclearTension #CellBiology #CellCycle #CellDivision #NuclearEnvelope #NuclearTranslocation #CellCompression #GenomicInstability