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Une nouvelle classe d'antibiotiques contre #Staphylococcus #Aureus (les staphilocoques dorés) découverts par une #IA

https://fr.euronews.com/next/2023/12/21/une-ia-decouvre-les-premiers-nouveaux-antibiotiques-depuis-plus-de-60-ans

Une IA découvre les premiers nouveaux antibiotiques depuis plus de 60 ans

Une nouvelle classe d'antibiotiques pour les bactéries "Staphylococcus aureus" résistantes aux médicaments (SARM) a été découverte en utilisant des modèles d'apprentissage profond plus transparents.

euronews

#Celldivision protein FtsK coordinates bacterial #chromosome segregation and daughter cell separation in #Staphylococcus #aureus
Helena Veiga, Mariana Pinho et al show #FtsK interacts with the #chaperone #Triggerfactor and establishes its gradient towards the #septum to promote stability and export of the #peptidoglycan #hydrolase Sle1.

https://www.embopress.org/doi/10.15252/embj.2022112140

„University Student Invents Solar Panels Made From Food Waste That Produce Energy Even Through Cloudy Weather“

https://www.awesomeinventions.com/solar-panels-aureus/

#goodnews #sustainability #savetheworld #AuREUS #goodstuff #inventions #savetheplanet #recycle

University Student Invents Solar Panels Made From Food Waste That Produce Energy Even Through Cloudy Weather

Your daily dose of geeky gadgets!

Awesome Inventions

A newly-released study suggests that a small group of gold #coins long considered to be 18th-century fantasies may in fact belong to an otherwise unknown 3rd-century #Roman usurper named #Sponsianus. Reaction is mixed. The open access paper can be found here: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0274285

#numismatics #Sponsian #aureus

Image below courtesy Wikimedia Commons https://commons.wikimedia.org/wiki/File:Sponsianus_Aureus.PNG#globalusage

Authenticating coins of the ‘Roman emperor’ Sponsian

The ‘Roman emperor’ Sponsian is known only from an assemblage of coins allegedly found in Transylvania (Romania) in 1713. They are very unlike regular Roman coins in style and manufacture, with various enigmatic features including bungled legends and historically mixed motifs, and have long been dismissed as poorly made forgeries. Here we present non-destructive imaging and spectroscopic results that show features indicative of authenticity. Deep micro-abrasion patterns suggest extensive circulation-wear. Superficial patches of soil minerals bound by authigenic cement and overlain by oxidation products indicate a history of prolonged burial then exhumation. These observations force a re-evaluation of Sponsian as a historical personage. Combining evidence from the coins with the historical record, we suggest he was most likely an army commander in the isolated Roman Province of Dacia during the military crisis of the 260s CE, and that his crudely manufactured coins supported a functioning monetary economy that persisted locally for an appreciable period.

Een #Romeinse gouden munt met de afbeelding van de onbekende #keizer #Sponsianus blijkt echt te zijn. De in 1713 in Roemenië gevonden #aureus werd lang als nep beschouwd. Sponsianus heerste mogelijk tussen 240 en 250 AD over Romeins gebied in Oost-Europa.
https://www.nu.nl/wetenschap/6238073/eeuwenoud-muntstuk-bewijst-dat-romeinse-nepkeizer-wel-degelijk-bestond.html
Eeuwenoud muntstuk bewijst dat Romeinse 'nepkeizer' wel degelijk bestond

Een Romeinse munt met de afbeelding van een keizer die lang voor nep werd gehouden, blijkt na onderzoek van University College London toch echt te zijn. Dat zou betekenen dat de keizer zelf echt bestaan heeft, schrijven The Guardian en BBC News.

NU

Nice  🧵 on #cefazolin, the antibiotic we all would choose for the treatment of severe #Staph #aureus infections if inoculum effect was not a concern.

https://twitter.com/drtimothyli/status/1591786659930308608?s=20&t=WxEaNrlguwOEqLMd87NmmQ

I have a question for the #Microbiology (MicroMastodon?) community in Mastodon:

Is there any feasible #proxy to inoculum effect in the Micro #Lab for selected cases?

Timothy Li on Twitter

“A few things about cefazolin 1.General •1st generation parenteral cephalosporin •Active against MSSA, Streptococci (A,B,C,G,viridans) and aerobic GNB (E.coli, Klebsiella, Proteus) •2 most common indications: MSSA BSI, pre-op prophylaxis”

Twitter

Ever wonder where #Staphylococcus #aureus/ #MRSA lab strains come from? In a new group #blog post, "Meet the Staph: A menagerie of common S. aureus reference strains", grad students Brooke Talbot and Vishnu Raghurum dish the details on 6 common strains and discuss how we could improve our choice of bacterial lab rats in the future.

https://emergent.emory.edu/blog/posts/reference_staph_aureus_blog_vr_edits/