Understanding the Principle of Independent Assortment in Genetics
#Alleles, #Chromosome, #CrossingExperiment, #DihybridCross, #Gene, #GregorJohannMendel, #Heterozygous, #IndependentAssortment, #LawOfSegregation, #Mendel, #Segregation, #Traits #Genetics In the intricate world of genetics, where traits are passed down from generation to generation, one fundamental principle governs the inheritance of multiple traits simultaneously: the Principle of Independent…
Navigating the Genetic Lexicon: Understanding Key Terminology in Genetics
#Alleles, #Chromosomes, #DNA, #DominantTraits, #Gene, #GeneticTerminology, #GeneticVariation, #GeneticsTerminology, #Genotype, #HomologousRecombination, #Mutations, #Nucleotides, #Phenotype, #RecessiveTraits #Genetics Genetics is a fascinating field that explores the blueprint of life encoded within our DNA. However, delving into this complex world often feels like deciphering a cryptic language…
#Alleles, #Chromosomes, #DNA, #DominantTraits, #Gene, #GeneticTerminology, #GeneticVariation, #GeneticsTerminology, #Genotype, #HomologousRecombination, #Mutations, #Nucleotides, #Phenotype, #Reces…
#Human ancestry has been shaped by mixing and matching #alleles, show two recent studies.
The course of human history has been marked by complex patterns of migration, isolation, and admixture, the latter a term that refers to gene flow between individuals from different populations. Admixture results in a blending of genetic lineages, leading to increased genetic diversity within populations. In addition to admixture among modern human populations, ancient humans reproduced with other hominin groups, such as Neanderthals and Denisovans.
Definitions 🧵:
A #haplogroup is a combination of #alleles that tend to be inherited together.
An #allele is a variation of the same sequence of nucleotides at the same place on a DNA molecule.
#Haplogroups pertain to a single line of descent. As such, individual membership of a haplogroup relies on a small proportion of the #genetic material possessed by that individual.
Mothers pass on mitochondrial #DNA unmixed to all their children; so the #ancestry can be traced along the maternal line.
It turns out that a section of our #DNA that we received from Neanderthals is particularly associated with outcomes (mild, severe) of #COVID19 infections.
This paper outlines an approach ranging from population genetics to functional #genomics in which the researchers identified four important #alleles and their likely #regulatory function.
Title: "Regulatory dissection of the severe #COVID-19 risk locus introgressed by #Neanderthals" (Jagoda et al. 2023)
Key functional variants, discovered using Massively Parallel Reporter Assay (MPRA) and reporter assays in the context of SARS-CoV-2 infection, support the importance of two critical chemokine receptor genes CCR1 and CCR5 in severe Covid-19 illness.
On the usefulness of the #SelfishGene metaphor popularized by #RichardDawkins in an eponymous #book:
"An Idea With Bite", Aeon (https://aeon.co/essays/why-the-selfish-genes-metaphor-remains-a-powerful-thinking-tool).
#Gene #Evolution #Chromosome #Darwin #Dawkins #CharlesDarwin #Mendel #Alleles #MolecularBiology #Genetics #Biology
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