Interesting talk by Clemens Richert at #Biochemistry2026. He talked about "Nucleoside Phosporamidates with Roles in Chemical Biology and Medicinal Chemistry".
#Virus #RNA #Nucleotides #Biochemistry #Chemistry #ChemBio #MedChem #MedicinalChemistry
CC: @gdch
SciTech Chronicles. . . . .May 11th, 2025
#sugars #nucleotides, #formaldehyde #"Abiotic aldol reactions" #photons #" photonic computing" #"matrix multiplications" #AI #StEnSea #"pump-turbine" #valve #400kWh #Norm #"Norman Diverter" #FRC #Confinement #tools #structures #Skye #Holocene
🧬 Can AI predict DNA structures better than traditional methods?
This study benchmarks DNA large language models (LLMs) in identifying G-quadruplexes (G4s)—special DNA structures linked to gene regulation, cancer, and therapeutics.
🔗 Benchmarking DNA large language models on quadruplexes. Computational and Structural Biotech Journal, DOI: https://doi.org/10.1016/j.csbj.2025.03.007
📚 CSBJ: https://www.csbj.org
#LargeLanguageModels #LLMs #DNA #RNA #Genomics #Nucleotides #AI
Hovlinc (Genetics 🧬)
Hovlinc RNA is a self-cleaving ribozyme of about 168 nucleotides found in a very long noncoding RNA in humans, chimpanzees, and gorillas. The word "hovlinc" comes from "hominin vlincRNA-located" RNA. Hovlinc is only a fourth known case of a ribozyme in human. Self-cleavage activity of Hovlinc has been shown in human, chimpanzees and bonobos, but is absent in gorillas...
https://en.wikipedia.org/wiki/Hovlinc
#Hovlinc #Rna #Genetics #Ribozymes #Nucleotides #GoTemplateErrors
Navigating the Genetic Lexicon: Understanding Key Terminology in Genetics
#Alleles, #Chromosomes, #DNA, #DominantTraits, #Gene, #GeneticTerminology, #GeneticVariation, #GeneticsTerminology, #Genotype, #HomologousRecombination, #Mutations, #Nucleotides, #Phenotype, #RecessiveTraits #Genetics Genetics is a fascinating field that explores the blueprint of life encoded within our DNA. However, delving into this complex world often feels like deciphering a cryptic language…
#Alleles, #Chromosomes, #DNA, #DominantTraits, #Gene, #GeneticTerminology, #GeneticVariation, #GeneticsTerminology, #Genotype, #HomologousRecombination, #Mutations, #Nucleotides, #Phenotype, #Reces…
Researchers develop artificial building blocks of life.
For the first time, scientists from the University of Cologne (UoC) have developed artificial nucleotides, the building blocks of DNA, with several additional properties in the laboratory, which could be used as artificial nucleic acids for therapeutic applications.
Creating a toolkit of #yeast strains that over-produce key cellular building blocks.
#amino_acids #nucleotides #bioengineering
https://phys.org/news/2024-02-toolkit-yeast-strains-key-cellular.html
Microbes such as bacteria and yeast are increasingly being used to produce components of medicines, biofuels, and food. Indeed, baker's yeast, also known as brewer's yeast or Saccharomyces cerevisiae, is responsible for the fermentation process used in making beer or bread, but it is also used at scale to produce other molecules of value for industry.
How does signaling via extracellular #nucleotides contribute to innate immunity? Systematic #P2Y receptor survey in human #macrophages shows some control #inflammatory #cytokines, others viral replication, and #P2Y11 uniquely combining both roles
Line Lykke Andersen et al Andreas Pichlmair
GDCh Division of Biochemistry
John Vaccaro (johniac)
CSBJ
Planetary Ecologist
micrordt
Scientific Frontline
CellBioNews
The EMBO Journal