ISOGGSep 5, 2025
“Moreover, we demonstrated that a higher FI score of mtDNA variants was associated with both premature epigenetic aging in the early 20s and premature biological aging in the late 20s." #isogg #DNA #epigenetics #haplogroups #geneadons
https://www.nature.com/articles/s41398-025-03235-4
Mitochondrial DNA variants and their impact on epigenetic and biological aging in young adulthood - Translational Psychiatry

The pace of biological aging varies between people independently of chronological age and mitochondria dysfunction is a key hallmark of biological aging. We hypothesized that higher functional impact (FI) score of mitochondrial DNA (mtDNA) variants might contribute to premature aging and tested the relationships between a novel FI score of mtDNA variants and epigenetic and biological aging in young adulthood. A total of 81 participants from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) prenatal birth cohort had good quality genetic data as well as blood-based markers to estimate biological aging in the late 20. A subset of these participants (n = 69) also had epigenetic data to estimate epigenetic aging in the early 20s using Horvath’s epigenetic clock. The novel FI score was calculated based on 7 potentially pathogenic mtDNA variants. Greater FI score of mtDNA variants was associated with older epigenetic age in the early 20s and older biological age in the late 20s. These medium to large effects were independent of sex, current BMI, cigarette smoking, cannabis, and alcohol use. These findings suggest that elevated FI score of mtDNA variants might contribute to premature aging in young adulthood.

Nature
Bibliolater 📚 📜 🖋Jul 7, 2025

**Further insights into maternal and paternal human histories in southern Iberia**

"_Genetic ancestry among Andalusians seems to be constituted by three foremost continental origins: European, African and Middle Eastern. The examined male group has revealed a noticeable proportion of individuals (over 45%) with a non-correspondence between maternal and paternal haplogroup origins, a signal of different population demographic histories linked to both sexes in the past._"

González-Barrio, M. et al. (2025) ‘Further insights into maternal and paternal human histories in southern Iberia’, Evolutionary Human Sciences, pp. 1–28. doi: https://doi.org/10.1017/ehs.2025.10006.

#OpenAccess #OA #DOI #Science #Genetics #Genome #Haplogroups #Ancestry #Iberia #Academia #Academics

Further insights into maternal and paternal human histories in southern Iberia | Evolutionary Human Sciences | Cambridge Core

Further insights into maternal and paternal human histories in southern Iberia

Cambridge Core
ISOGGDec 17, 2024

“Newfoundland/Labrador is an excellent example of a population exhibiting founder effects resulting from limited genetic input followed by generations of geographical and societal isolation which led to regional expansion of specific haplogroups.” #isogg #dna #haplogroups #Newfoundland #Labrador

https://www.nature.com/articles/s41431-024-01719-3

Characterization of Y chromosome diversity in newfoundland and labrador: evidence for a structured founding population - European Journal of Human Genetics

The population of Newfoundland and Labrador (NL) is largely derived from settlers who migrated primarily from England and Ireland in the 1700s–1800s. Previously described as an isolated founder population, based on historical and demographic studies, data on the genetic ancestry of this population remains fragmentary. Here we describe the largest investigation of patrilineal ancestry in NL. To determine the paternal genetic structure of the population, 1,110 Y chromosomes from an NL-based cohort were analyzed using 5,761 Y-specific SNPs. We identified 160 distinct terminal haplogroups, the majority of which (71.4%) belong to the R1b haplogroup. When compared with global reference populations, the NL population haplogroup composition and frequencies primarily resemble those observed in English and Irish ancestral source populations. There is also evidence of genetic contributions from Basque, French, Portuguese, and Spanish fishermen and early settlers who frequented NL. Interestingly, the observed population structure shows geographical and religious clustering that can be associated with the settlement of the ancestral source populations from predominantly Protestant, England, and Catholic, Ireland respectively. For example, the R1b-M222 haplogroup, seen in people of Irish descent, is found clustered in the Irish-settled Southeast region of NL. The clustering and expansion of Y haplogroups in conjunction with the geographical and religious clusters illustrate that limited subsequent in-migration, geographic isolation, and societal factors have contributed to the genetic substructure of the NL population and its designation as a founder population.

Nature
ISOGGDec 11, 2024

Do Haplogroups H and U Act to Increase the Penetrance of Alzheimer’s Disease? #dna #isogg #alzheimers #haplogroups

https://tinyurl.com/44w677xs

ISOGGDec 10, 2024

“Our findings suggest that mtDNA haplogroups can play a role in Covid-19 pathogenesis, thus potentially useful in identifying susceptibility to its severe form.” #DNA #isogg #epigenetics #covid #mtDNA #mitochondria #haplogroups

https://www.sciencedirect.com/science/article/pii/S1567724923001071

ISOGGJul 31, 2024

“RNASeq analyses suggest Y-chromosome gene expression differs between brain and blood tissues but does not differ significantly in cases, controls or specific haplogroups. Overall, we did not find any strong associations between Y-chromosome genetics and Parkinson's disease, suggesting the explanation for the increased prevalence in males may lie elsewhere.” #isogg #dna #YDNA #Parkinsons #haplogroups #geneadons

https://pubmed.ncbi.nlm.nih.gov/36387750/

Analysis of Y chromosome haplogroups in Parkinson's disease - PubMed

Parkinson's disease is a complex neurodegenerative disorder that is about 1.5 times more prevalent in males than females. Extensive work has been done to identify the genetic risk factors behind Parkinson's disease on autosomes and more recently on Chromosome X, but work remains to be done on the ma …

PubMed
KennethJul 19, 2024

Gives new meaning to the term "The Coming Race".

#Haplogroups
#Eugenics
#Racism

KennethJul 19, 2024

One guy in Canada found out that he'd biologically fathered 40 children. He had to go into therapy.

Some Dutch wacko fathered more than a hundred. The courts told him to knock it off. Or perhaps just to jack off.

And don't get me started on Genghis Khan...

#Haplogroups
#eugenics
#racism

KennethJul 19, 2024

This might lead to issues, though. There have been scandals at sperm banks, and Iceland of course is out of the running. (Dating apps in Iceland, and for matter Ireland and Alabama, calculate consanguinity).

#Haplogroups
#Eugenics
#racism

KennethJul 19, 2024

Along the lines of Patient Zero, I hereby declare myself Haplo Lord Zero.

Be right back, exercising my droit du seigneur.

#Haplogroups
#eugenics
#racism