✨ What secret molecular partnership helps mycobacteria stay alive when conditions turn deadly?
🔗 Structural modeling and biochemical characterization of MSMEG_0748, a MoxR ATPase from Mycobacterium smegmatis. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.11.010
📚 CSBJ: https://www.csbj.org/
#Mycobacterium #MoxR #ATPase #AlphaFold #StructuralBiology #Biophysics #Microbiology #MolecularModeling
Black Tailed Prairie Dog Laying on Back 🇺🇸
#10cmpetridish #2d #A #AIDS #ATPase #Acinus(Pancreas) #Bafilomycin #Blood;red;icon;droplet
⏩ 109 new pictures from NIH BioArt https://commons.wikimedia.org/wiki/Special:ListFiles?limit=378&user=OptimusPrimeBot&ilshowall=1&offset=20251127003524
Discovery of #amino_#acid unveils how light makes #stomata open in #plants.
#ATPase #Thr881 #proton_pump #photosynthesis #transpiration
https://phys.org/news/2024-03-discovery-amino-acid-unveils-stomata.html
Scientists from Nagoya University have discovered a novel regulatory mechanism that controls the opening of stomata in plants, which is crucial for harnessing solar energy through photosynthesis. The team uncovered the role of phosphorylation at the 881st threonine residue (Thr881) of the plasma membrane proton pump in response to red and blue light in this process.
Combining unique methods, researchers discover new #protein functions, explore physical space of proteins.
#DNA #replication #clamp_loaders #ATPase
https://phys.org/news/2024-02-combining-unique-methods-protein-functions.html
Researchers in the lab of John Kuriyan, professor of biochemistry and dean of the School of Medicine Basic Sciences, have revealed a key element of how a molecular machine responsible for high-speed DNA replication works. The results of their study build on growing theories of molecular evolution.
A close-up of biological #nanomachines: Researchers take a deep look at #peroxisomal processes.
https://phys.org/news/2023-09-close-up-biological-nanomachines-deep-peroxisomal.html
Every system has its waste disposal system. The cell organelles known as "peroxisomes" dispose of toxic substances and fats in the human body, among other things, and, in doing so, they prevent serious illnesses. The "Pex" group of proteins (peroxisomes biogenesis factors) keep these "detox units" functioning properly.
Phenomenal #phytoplankton: Scientists uncover cellular process behind #oxygen production.
#photosynthesis #proton_pumps #VHA #ATPase
https://phys.org/news/2023-05-phenomenal-phytoplankton-scientists-uncover-cellular.html
Take a deep breath. Now take nine more. According to new research, the amount of oxygen in one of those 10 breaths was made possible thanks to a newly identified cellular mechanism that promotes photosynthesis in marine phytoplankton.
Ancient animal Dicer used its helicase domain to couple the detection of foreign double-stranded RNA to efficient ATP hydrolysis and antiviral defense, but this function declined before the advent of deuterostomes and vertebrates.
Unwinding the world's smallest #biological rotary #motor by degrees.
https://phys.org/news/2023-03-unwinding-world-smallest-biological-rotary.html
Adenosine triphosphate (ATP) is the energy currency of cells. It powers various cellular processes that require energy, including enzymatic reactions. ATP is synthesized with the help of an enzyme complex called F-type ATP synthase. This enzyme complex has a bidirectional functionality, working to synthesize ATP as well as hydrolyzing it, depending on environmental and cellular cues.
The human AAA+ ATPase CLPB (SKD3) is a protein disaggregase in the mitochondrial intermembrane space that promotes the solubilization of various mitochondrial proteins. This structural and functional study of CLPB provides insights into its assembly and mechanism of action.
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