Masaru Koido

40 Followers
14 Following
11 Posts
Assistant Professor, Univ. of Tokyo.
Visiting Scientist, RIKEN IMS.
Interest: Complex Trait #Genomics | Transcriptional Regulation
Approach: #MachineLearning | #Statistical Modeling
CV (Researchmap)https://researchmap.jp/mkoido?lang=en
GitHubhttps://github.com/koido
Twitterhttps://twitter.com/m_koido

I'm excited to share a preprint of CAMBUS, a new DNA machine-learning application to identify "constrained" open chromatin regions (OCRs)!
By leveraging cell-type-specific OCRs, CAMBUS prioritized causal variants in a cell-type-specific manner.

This work was also presented as a platform talk at the #ASHG meeting last year.

https://www.biorxiv.org/content/10.1101/2024.10.31.621195v1

We are excited to announce that Wes McKinney has joined Posit!

When we changed our name to Posit, our goal was to unify efforts around creating great tools for #datascience, regardless of language, and working with Wes is a huge step forward in realizing that dream.

#python

Our work to derive hidden knowledge from #spatialtranscriptome by deep learning (DeepSpaCE) was one of the top 100 downloaded cancer papers for Scientific Reports in 2022!

According to https://www.nature.com/collections/ciijehjfha, our paper was ranked 9th in the cancer papers. I will continue to work on developing new methods to encourage data-driven science!

Paper: https://nature.com/articles/s41598-022-07685-4
Tool (DeepSpaCE): https://github.com/tmonjo/DeepSpaCE (ready-to-use for #Visium data).

Top 100 in Cancer - 2022

Most downloaded Scientific Reports articles in cancer research published in 2022

Nature
Our machine learning paper (https://rdcu.be/c15v4) was highlighted in News & Views in Nat Biomed Eng.  

Predicting pathogenicity from non-coding mutations
https://rdcu.be/c15v2

RT @[email protected]

Check out our Perspective in @[email protected] highlighting 7 challenges to be considered in the study of enhancer dysfunction in disease.
👏 @[email protected] @[email protected] @[email protected] & @[email protected] for coordinating this work.
@[email protected]
➡️ https://rdcu.be/c1f7d

🐦🔗: https://twitter.com/enhpathy_H2020/status/1600901519850835969

Springer Nature Shairdit for my MENTR paper in Nat Biomed Eng is available here
https://rdcu.be/cZ70K

Our work to predict transcription of #ncRNA, especially for #eRNA, from DNA sequences is finally out in @[email protected].
Our machine learning tool, MENTR, is available at https://github.com/koido/MENTR. MENTR can link non-coding #GWAS associations and cell-type-specific #ncRNA expressions!

https://www.nature.com/articles/s41551-022-00961-8

This was my main work in @[email protected] lab in @[email protected]. Many thanks to excellent collaborators, amazing #FANTOM5 datasets, and GPU supercomputer #ABCI.

GitHub - koido/MENTR

Contribute to koido/MENTR development by creating an account on GitHub.

GitHub

#introduction

I'm an assistant professor (non-tenure) at the University of Tokyo, #Japan.
I'm a bioinformatician working on complex trait #genomics utilizing #MachineLearning and statistical modeling on #GWAS results and #omics datasets. I'm especially interested in #humangenetics and transcriptional regulation.