Ariel K. Frame

16 Followers
20 Following
30 Posts
BSc Biology || PhD Neuroscience || Postdoc with Andrew Lin at University of Sheffield || Drosophila, aging, learning and memory, neurobiology. Host: linktr.ee/quitecurious bit.ly/ArielFrame_GoogleScholar
First episode of my podcast is out! I spoke with Professor James Marshall
at University of Sheffield about his research on modelling the #brain of #bees and implications for #ai. Take a listen! #neuroscience #sciencecommunication
Check out this summary of the split-GAL4 method development over the past 10 years. Good resource. https://www.biorxiv.org/content/10.1101/2024.01.09.574419v1
@Michael__Rera Thanks! I was asking for mice this time haha
@Michael__Rera Do you have any preliminary data on how many animals might be necessary to have an adequately powered study for measuring ageing with the Smurf assay? Including males and females?
@katvogt Nice article!
@MarkHanson @wolfhuette Their criterion 1 also says ‘immediate’. The Burghardt book they cite provides a lengthy explanation for the criteria used, and this includes much nuance that they don’t have space for in the paper. I think that there is enough ambiguity and controversy around the definition of 'play' that caveating the claim by calling it 'play-like' is sufficient for me. How play-like? Maybe minimally. That’s where further study is needed, with sticks and predators etc.
@MarkHanson @wolfhuette I think there are likely many contexts in which one could test whether this type of behaviour varies to determine more deeply what motivates flies to engage in it; be it enjoyment, utility, or both. For predator avoidance, testing with predator cues present may clarify. But, even if more testing reveals compelling evidence for this truly being play-like behaviour, for me this wouldn’t reach the threshold of altering ethical implications. Why would it for you?
@MarkHanson @lmvteixeira Wow. Certainly something I’m going to keep in mind going forward.
After plenty of nurturing, my #preprint baby has now matured into a fully formed publication in Aging. https://doi.org/10.18632/aging.204565 This #Drosophila study on #lactate #brainmetabolism, #Aging and #Memory is my first paper including data from my PhD thesis. I’ve got a couple more papers up my sleeve before I graduate this summer. Keeping my eyes out for #postdoc positions studying aging and behaviour in flies.
Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies | Aging

Aging | doi:10.18632/aging.204565. Ariel K. Frame, J. Wesley Robinson, Nader H. Mahmoudzadeh, Jason M. Tennessen, Anne F. Simon, Robert C. Cumming

@MarkHanson That’s amazing you caught that. How prevalent do you think this virus is in Drosophila labs around the world? Is there a simple way to ensure lab stocks don’t have it?