Technische Universität MünchenResearchers developed an enzymatic #oxygenscavenger that brings the accuracy of oxidase-based #biosensors for #glucose, #lactate and #creatinine from 50% up to 99%, paving the way for new uses: http://go.tum.de/432668
📷A. Heddergott
Misiunea Bucovina🐮 "O țin pentru un pic de lapte, să fac brânză..."
👉 Broșteni încă are nevoie de ajutorul tau!
❗️Donează cu specificația: Darul din Ogradă
SagitturaA #lactate curve is shaped by the tension between #anaerobic and #aerobic capacity. Judging a curve by only the latter is incomplete and error prone.
RDNA mouse study found that lactate, whether produced by exercise or administered exogenously, reduces cognitive impairment. This provides a potential explanation for the effects of exercise in mitigating the effects of Alzheimer's disease.
https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-025-04168-x
Lactate links exercise to synaptic protection and cognitive enhancement in Alzheimer’s disease models - BMC Medicine
Background Physical exercise is known to promote cognitive resilience in aging and Alzheimer’s disease (AD), but the underlying mechanisms remain incompletely understood. Lactate, a metabolic byproduct elevated during exercise, has recently emerged as a potential neuromodulator of brain function. Methods Three AD-like mouse models (SAMP8, Aβ1-42 injection, and 5xFAD) were used to evaluate the effects of treadmill exercise on cognitive function and synaptic plasticity. Serum lactate levels were assessed, and sodium L-lactate (NaLA) was administered to determine its neuroprotective effects. Transcriptomic analysis was performed on hippocampal tissue to explore lactate-regulated pathways. Lactate transport was pharmacologically inhibited using 4-CIN for mechanistic validation. Results Treadmill exercise significantly improved cognitive performance and increased synapse-associated protein expression in AD models. Exercise elevated serum lactate levels, and exogenous NaLA administration recapitulated the cognitive and synaptic benefits of exercise. Transcriptomic profiling revealed enrichment of genes involved in axon guidance and synaptic organization, including upregulation of multiple Eph receptor family genes. α-cyano-4-hydroxycinnamic acid (4-CIN) administration abolished the exercise-induced neuroprotective effects, confirming the essential role of lactate transport in mediating these benefits. Conclusions This study identifies lactate as a critical mediator linking exercise to enhanced synaptic function and cognitive improvement in AD-like models, providing mechanistic insights and highlighting lactate metabolism as a potential therapeutic target for AD.
McDuckFanficMilking The Singers
#troubadour
#princess
#thebrementownmusicians
#sovietcartoon
#soyuzmultfilm
#nude
#naked
#milk
#milking
#blonde
#embarassed
#cum
#lactate
Yummy
Nicolas Clairishttps://direct.mit.edu/imag/article/doi/10.1162/imag_a_00452/127397/Functional-magnetic-resonance-spectroscopy-of nice fMRS paper measuring lactate in the motor cortex at 3T! #fMRS #lactate
RhyothemisNew findings: more evidence of poor oxygen perfusion in the brain
https://youtu.be/g4hLI5ktOhE?si=6vbxMnDAGKCfUNsd
"We seeing high levels of lactate and low levels of choline in the brains of Gulf War Illness sufferers. This quick update covers our new analyses and why the may be important to those with chronic pain, fatigue, and cognitive issues. - Jarred Younger"
#GulfWarIllness #ChronicIllness #ChronicPain #choline #lactate
#BrainPerfusion
#MECFS
Howard Smith MD, AMInstead of a blood stick use your sweat! Washington State University bioengineers have successfully 3D printed a flexible patch with multiple micro channels for colorimetric bioassays for up to 3 biomarkers. #sweat #glucose #uricacid #lactate #diabetes #gout #exercise
https://www.instagram.com/p/C8qsViRRAge/
https://www.instagram.com/p/C8qsViRRAge/
Matt WillemsenBrain Acidity Linked With Multiple Neurological Disorders
https://www.sciencealert.com/brain-acidity-linked-with-multiple-neurological-disorders #psychology #BrainAcidity #Neurological #Disorders #metabolic #dysfunction #lactate #pH
https://www.sciencealert.com/brain-acidity-linked-with-multiple-neurological-disorders #psychology #BrainAcidity #Neurological #Disorders #metabolic #dysfunction #lactate #pH
