Neuroscientist, Father, Husband, Son, Brother, Friend, Citizen. aka @AllenNeuroLab on Twitter
Director of the Neurocircuitry & Cognition Lab at FIU, visit http://allenlab.fiu.edu, #neuroscience #hippocampus #prefrontal #thalamus #memory #yale #uci #csulb
| Website | http://allenLab.fiu.edu |
Interested in how the nucleus reuniens organizes neural activity in the hippocampus and prefrontal cortex supporting memory? #neuroscience #memory #hippocampus #neuropaper
Check our our new paper by co-first authors Drs. Tatiana Viena and Maanasa Jayachandran. Congrats to all authors--simply an amazing team!
The prefrontal cortex interacts with the hippocampus to guide memory, but the mechanisms driving functional connectivity are unknown. Here, the authors demonstrate that the nucleus reuniens elicits synchronizations at beta (15–30 Hz) rhythms during retrieval.
“Identifying the midline thalamus in humans in vivo” by Reeders et al.
now online in Brain Structure & Function! #neuroscience
https://link.springer.com/article/10.1007/s00429-022-02607-6
The midline thalamus is critical for flexible cognition, memory, and stress regulation in humans and its dysfunction is associated with several neurological and psychiatric disorders, including Alzheimer’s disease, schizophrenia, and depression. Despite the pervasive role of the midline thalamus in cognition and disease, there is a limited understanding of its function in humans, likely due to the absence of a rigorous noninvasive neuroimaging methodology to identify its location. Here, we introduce a new method for identifying the midline thalamus in vivo using probabilistic tractography and k-means clustering with diffusion weighted imaging data. This approach clusters thalamic voxels based on data-driven cortical and subcortical connectivity profiles and then segments the midline thalamus according to anatomical connectivity tracer studies in rodents and macaques. Results from two different diffusion weighted imaging sets, including adult data (22–35 years) from the Human Connectome Project (n = 127) and adolescent data (9–14 years) collected at Florida International University (n = 34) showed that this approach reliably classifies midline thalamic clusters. As expected, these clusters were most evident along the dorsal/ventral extent of the third ventricle and were primarily connected to the agranular medial prefrontal cortex (e.g., anterior cingulate cortex), nucleus accumbens, and medial temporal lobe regions. The midline thalamus was then bisected based on a human brain atlas into a dorsal midline thalamic cluster (paraventricular and paratenial nuclei) and a ventral midline thalamic cluster (rhomboid and reuniens nuclei). This anatomical connectivity-based identification of the midline thalamus offers the opportunity for necessary investigation of this region in vivo in the human brain and how it relates to cognitive functions in humans, and to psychiatric and neurological disorders.
So you might think theta dominates hippocampal and prefrontal interactions during periods of high memory demand? Not during nonspatial sequence memory actually! We find very clear evidence that delta-beta states actually dominate nonspatial memory driven by thalamic reuniens, the cognitive thalamus. #neuroscience
https://www.biorxiv.org/content/10.1101/2022.06.21.497087v1.full
We're looking forward to #SfN22! We have five posters linked here: https://allenlab.fiu.edu/join-the-allenlab-at-sfn2022-in-san-diego/ or through the stylish QR code inserted at the bottom made by lab alumnus Dr. Jayachandran (now at NIMH/NINDS).
New SciMastodon friends and all invited -- come by, say "hi" and stay for some really cool #neuroscience from a great team!
Hello SciMastodon! Let’s neuroscience! This is my first post here so I put one of my favorite brains in the pic. Can you name the species?
Please do let me know how to follow all you neuroscience folks (and related scientists) so I can get in the conversation — just toot your handle at me! Did I use the that term correctly? 🤷♂️
