Stephan HackerGreat @LED3hub Lecture by Peng Chen. He talked about genetic code expansion in combination with in-cell chemistry to understand biology and develop therapeutics. Great insights into studying protein function with spatiotemporal resolution. (1/3)
He also gave exciting insights into RNA codon expansion using programmable editing of uridine to pseudouridine to convert a stop codon into an amino acid-coding codon. (2/3)
RNA codon expansion via programmable pseudouridine editing and decoding - Nature
An RNA codon-expansion strategy enables incorporation of non-canonical amino acids into proteins of interest orthogonally to existing methods by inserting pseudouridine codons into specific mRNA transcripts and using an engineered decoder tRNA.
Finally, he talked about the development of trimeric engagers (Multi-TACs) that can specifically bring together three different cell types. (3/3)
https://www.sciencedirect.com/science/article/pii/S009286742401198X
#Genetics #GeneticCodeExpension #ChemBio #Chemistry #Protein #RNA #GeneticCode #RNACodonExpansion