Grocery inflation has hit its highest level in nearly two years – The Journal
Grocery inflation has hit its highest level in nearly two years The JournalGrocery price inflation hits 6.5% in October RTE.ieGrocery…
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https://www.newsbeep.com/197650/
We propose a Hybrid High-Order (HHO) formulation of the incompressible Navier--Stokes equations with variable density that provides exact conservation of volume and, accordingly, pure advection of the density variable. The spatial discretization relies on hybrid velocity-density-pressure spaces and the temporal discretization is based on Explicit Singly Diagonal Implicit Runge-Kutta (ESDIRK) methods. The formulation possesses some attractive features that can be fruitfully exploited for the simulation of mixtures of immiscible incompressible fluids, namely: pressure-robustness, conservation of volume enforced cell-by-cell up to machine precision, robustness in the convection dominated regime thanks to upwind stabilizations, weak imposition of boundary conditions, implicit high-order accurate time stepping encompassing unsteady boundary conditions, reduced memory footprint thanks to static condensation, possibility to exploit inherited $p$-multilevel solution strategies to improve performance of iterative solvers. Numerical validation is performed showcasing convergence rates, pressure-robustness and pure advection of the density, thus we tackle the Rayleigh-Taylor instability at Reynolds $1~000$ and $5~000$.
The glider instruments need to be tested in a more holistic way...as holistic as you can get when the fuselage is sitting in the garage.
First photo shows tubing attached to the pitot probe. The long external tube allows me to add pressure to the pitot system while looking at the instruments on the panel.
Second photo shows the airspeed indicator (small round display) and glide computer screens. Both of those systems have pitot pressure sensors. I have pressurized the external tubing so that the airspeed indicator shows about 105 knots indicated airspeed. As you can see in the lower part of the glide computer display (V IAS)...the two devices agree within about 1 knot. I can't ask for better than that. (The vario also has a pitot pressure input, but it also uses GPS. It's very confused and angry that GPS says the glider is stationary, but it's supposedly moving through the air at a ridiculous speed. I may have to wait until flight testing to really evaluate the total-system performance of this advanced vario.)
Another bit of good news is that the leakage rate of the pressurized and sealed pitot system is pretty low. After a minute or two the indicated airspeed only drops a few percent at the most. That's not perfect, but it's pretty good.
Third photo shows what the instrument panel looks like when all the devices/screens are running. That's right, if I lose electrical power, my instrument panel is a blank, black hole.
Since I powered up all the screens, it means I'm ready to hook up an ammeter to measure current draw of each device, and my maximum load when everything is running. I'll do that tomorrow.
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#Vermont State Senator Samuel #Douglass will resign after participating in racist Young Republican group chat. | My Nazi Senator.
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> The Vermont state senator who’s been under #pressure to resign since revelations surfaced this week of his participation in a racist group chat announced Friday evening that he’s leaving public office.
The dissipation mechanisms in weakly collisional plasmas have been a longstanding topic of investigation, where significant progress has been made in recent years. A recent promising development is the use of the "scale-filtered" Vlasov-Maxwell equations to fully quantify the scale-by-scale energy balance, a feature that was absent when using fluid models in kinetic plasmas. In particular, this method reveals that the energy transfer in kinetic scales is fully accounted for by the scale-filtered pressure-strain interaction. Despite this progress, the influence of ion-electron thermal disequilibrium on the kinetic-scale energy budget remains poorly understood. Using two-dimensional fully kinetic particle-in-cell simulations of decaying plasma turbulence, we systematically investigate the pressure-strain interaction and its components at sub-ion scales by varying electron-to-ion temperature ratios. Our analysis focuses on three key ingredients of the pressure-strain interaction: the normal and shear components of Pi-D and pressure dilatation. Our results demonstrate that the scale-filtered pressure-strain interaction is dominated by scale-filtered Pi-D across the kinetic range, with the shear component consistently providing the dominant contribution. We find that the scale-filtered normal and shear contributions of Pi-D exhibit persistent anticorrelation and opposite signs across all kinetic scales. We also discover that the amplitude of both anisotropic components for each species scales directly with their temperature and inversely with the temperature of the other species, while the scale-filtered pressure dilatation remains negligible compared to the Pi-D terms but shows enhanced compressibility effects as plasma temperatures decrease. We discuss the implications of these findings in thermally non-equilibrated plasmas, such as in the turbulent magnetosheath and solar wind.
Background: Lipid peroxidation and iron accumulation are hallmarks of ferroptosis, a form of cell death characterized by iron-dependent oxidative damage to cellular membranes. However, the molecular link between lipid peroxidation and iron overload in the execution of ferroptosis remains elusive. Moreover, the pathophysiological implications of the interaction between lipid peroxidation and iron overload in cardiac homeostasis and remodeling are also unknown. Methods: We assessed the role of lipid peroxidation in mediating cardiac iron overload and ferroptosis using genetic mouse models. We also performed molecular and cellular biology studies to elucidate the mechanisms by which lipid peroxidation regulates iron homeostasis and ferroptosis signaling in cardiomyocytes. Results: Cardiomyocyte-specific ablation of Gpx4 (glutathione peroxidase 4), a key suppressor of lipid peroxidation, promoted iron overload and ferroptosis in the heart, leading to dilated cardiomyopathy. Mice with heterozygous Gpx4 knockout were also predisposed to adverse cardiac remodeling and dysfunction following pressure overload. Mechanistically, elevated lipid peroxidation due to GPX4 inactivation intrinsically induced iron overload by promoting the nuclear export of Bach1 and subsequent induction of heme oxygenase-1 (HO-1). Genetic and pharmacologic inhibition of HO-1 markedly attenuated iron overload and ferroptosis in cardiomyocytes and rescued dilated cardiomyopathy associated with Gpx4 deficiency. Moreover, we identified HO-1 mitochondrial translocation as a key mechanism driving mitochondrial iron overload and ferroptosis. Targeted inhibition of mitochondrial iron overload or lipid peroxidation abrogated cardiac ferroptosis and pathological remodeling induced by Gpx4 deficiency. Conclusions: These findings identified a mechanistic link between lipid peroxidation and iron overload via the Bach1-HO-1 signaling pathway, revealing new regulators and molecular targets for cardiac ferroptosis. ### Competing Interest Statement The authors have declared no competing interest.
#Vermont State Senator Samuel #Douglass will resign after participating in racist Young Republican group chat. | My Nazi Senator.
#vtdems #vtpol
> The Vermont state senator who’s been under #pressure to resign since revelations surfaced this week of his participation in a racist group chat announced Friday evening that he’s leaving public office.
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