michaelJul 4, 2025

I gather this is about reconstructing #ribosome #assembly in the #nucleolus - the PR is a bit wild but may be worth looking at the paper in Nature.

https://www.eurekalert.org/news-releases/1089618 #science #nanoworld #CellBiology #structuralBiology

New tool allows researchers to track assembly of cells’ protein-making machines

With a new mapping tool, Princeton engineers have revealed how a factory inside cells builds ribosomes, the machinery responsible for protein synthesis. The system opens the door to treatments and medicines.

EurekAlert!
preLightsApr 11, 2024

Find out how genome loci are anchored to the nucleolus! ⚓

Exciting new #preprint from #Trono_Lab shows that ZNF274 competes with CTCF to keep H3K9me3 silenced genome at the nucleolus periphery, fine-tuning cell-specific gene expression.

First preLights post from Silvia Carvalho! ⬇️ 👀

#preLight 👉 https://prelights.biologists.com/highlights/clusters-of-lineage-specific-genes-are-anchored-by-znf274-in-repressive-perinucleolar-compartments/

#biology #nucleolus #expression #genome

Clusters of lineage-specific genes are anchored by ZNF274 in repressive perinucleolar compartments - preLights

Find out how genome loci are anchored to the nucleolus! Exciting new study from @Trono_Lab shows that ZNF274 competes with CTCF to keep H3K9me3 silenced genome at the nucleolus periphery, fine-tuning cell-specific gene expression

preLights
PLOS BiologyNov 10, 2023
How do proteins sort into non-membrane bound compartments like the #nucleolus? This study shows that while some proteins starts with having an #IntrinsicallyDisorderedDomain, enhanced localization may require being part of larger complex #PLOSBiology https://plos.io/3QQvNEj
Intrinsically disordered regions are not sufficient to direct the compartmental localization of nucleolar proteins in the nucleus

How do proteins sort into non-membrane bound compartments like the nucleolus? This study shows that while for some proteins it starts with having an intrinsically disordered domain, enhanced localization may require being part of larger complex.

Journal of Experimental BotanySep 7, 2023

🥬 #Iron, an important #micronutrient, is stored inside the #nucleolus, as well as in chloroplasts and mitochondria
🥬 As a key ligand, #nicotianamine (NA), determines intracellular distribution of essential metals
🥬 NA is synthesised by the enzyme NICOTIANAMINE SYNTHASE (NAS)
🥬 This study used mutant #Arabidopsis plants with altered NAS activity to investigate nucleolar iron accumulation and the impact on #rDNA silencing and RNA #methylation

📖 https://doi.org/10.1093/jxb/erad180

#redox

NICOTIANAMINE SYNTHASE activity affects nucleolar iron accumulation and impacts rDNA silencing and RNA methylation in Arabidopsis

Low iron in the nucleolus and RNA modification changes suggest a central role of nicotianamine synthesis in rRNA gene expression.

OUP Academic
CellBioNewsAug 15, 2023

Study explains how part of the #nucleolus #evolved.

#organelles #TCOF1 #condensates #fibrillar_center

https://phys.org/news/2023-08-nucleolus-evolved.html

Study explains how part of the nucleolus evolved

Inside all living cells, loosely formed assemblies known as biomolecular condensates perform many critical functions. However, it is not well understood how proteins and other biomolecules come together to form these assemblies within cells.

Phys.org
CavalliLabFeb 1, 2023
Anchoring #3Dgenome & #chromatin contacts to #cellnucleus landmarks: Mapping #nucleolus-associated chromatin interactions using nucleolus #HiC reveals pattern of #heterochromatin interactions.
@NatureComms https://doi.org/10.1038/s41467-023-36021-1