Kendrew's 1962 #Nobel lecture is a great read for insight into the history of #structuralbiology, including the massive experimental effort to eke out the structure of #myoglobin. This required calculating Fourier transforms of thousands of reflexions, requiring the latest (at the time) #supercomputers like the first EDSAC digital computer and #IBM 7090
https://www.nobelprize.org/uploads/2018/06/kendrew-lecture.pdf
