Our latest #preprint https://www.biorxiv.org/content/10.1101/2022.01.11.475913v2 @jdmatheson calls for significant change to the theory of #BackgroundSelection, a phenomenon by which some genomic segments of some individuals don’t count toward an #EffectivePopulationSize because they contain too many deleterious mutations. 1/5

#MolecularEvolution #PopulationGenetics #MutationLoad #EvolgenPaper

Any math person here willing to review my heavy-math thesis chapter? It is around ~7000 words, beyond my supervisors' expertise, and I need to submit by March so he/she/they needs to have a lot of free time this February 🙃

Keyword: #mutationload #aDNA #PopulationGenetics #conservation #SIFT #phyloP #phastCons

I have nothing except I owe you one.

Any math person here willing to review my heavy-math thesis chapter? It is around ~7000 words, beyond my supervisors' expertise, and I need to submit by March so he/she/they needs to have a lot of free time this February 🙃

Keyword: #mutationload #aDNA #PopulationGenetics #conservation #SIFT #phyloP #phastCons

I have nothing except I owe you one.

#introduction I mostly work using in silico experiments and mathematical modeling to understand how properties of biological systems affect their evolution. Some of the topics I have studied include:

The effect of #epistasis in the accumulation and purging of deleterious mutations in organisms with high mutation rates. #mutationload

How the #modularity of
#DevelopmentalProcesses affect the #PhenotypicVariability of biological systems. #IntroductionBias